Carrie Bearden

Dr. Carrie Bearden received her Ph.D. in Clinical Psychology from the University of Pennsylvania in 1999. From 2000 to 2001 she received training in adult and pediatric neuropsychology, during her internship at the San Diego VA Medical Center and UCSD Child & Adolescent Psychiatry Services. From 2001 to 2002, Dr. Bearden became a Postdoctoral Fellow under an NIMH Neuroscience Training Grant at the Childrens Hospital of Philadelphia, where she obtained further experience in pediatric cognitive neuroscience. Dr. Bearden joined the UCLA faculty as Assistant Professor in the Department of Psychiatry & Biobehavioral Sciences at UCLA in 2003. She hold a secondary appointment in the Department of Psychology. She has received numerous awards and honors, including Young Investigator Awards from the International Congress for Schizophrenia Research and the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD), and the American College of Neuropsychopharmacology (ACNP), the A.E. Bennett Neuropsychiatric Research Award for Clinical Science in Biological Psychiatry, and the Samuel Gershon Junior Investigator Award from the International Society for Bipolar Disorders. Dr. Bearden’s research aims to understand genetic influences on brain structure in the development of psychosis, using converging methods to study cognition and neuroanatomy in clinical high-risk samples (e.g., adolescents at ultra high-risk for psychosis), and in possible ‘genetic subtypes’ of the disease with very high penetrance (e.g, 22q11.2 microdeletions). Another active research project, conducted in collaboration with Dr. Nelson Frimer, is an NIMH-funded study of neural endophenotypes of bipolar disorder in a genetically isolated population in Latin America.

Mailing Address:	300 Medical Plaza Suite 2265 Los Angeles , CA 90095 UNITED STATES

Group Home Page Redirect:	http://www.mrrc.npi.ucla.edu/

Additional information

Contact details

Site:

Semel Institute/NPI

Faculty Details

DGSOM FDB ID:

74845

Primary Appointment:

Psychiatry

Secondary Appointment:

Psychology

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Research Interests

Genetics and Neuroimaging of Mood Disorder and Psychosis

Dr. Carrie Bearden is a Clinical Neuropsychologist and Assistant Professor-in-Residence in the UCLA Department of Psychiatry and Biobehavioral Sciences. Dr. Bearden's primary research interest is in identifying brain-based traits ('endophenotypes') that may provide clues as to the underlying etiology of psychosis and bipolar disorder. Dr. Bearden received her Bachelors degree in psychology from UC Berkeley in 1993, and her Ph.D. in clinical psychology from the University of Pennsylvania in 1999.

Publications

Karlsgodt, Niendam, Bearden, Cannon White Matter Integrity and Prediction of Social and Role Functioning in Subjects at Ultra-High Risk for Psychosis.. Biological psychiatry. 2009; .

Niendam Tara A, Berzak Jodi, Cannon Tyrone D, Bearden Carrie E Obsessive compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcome.. Schizophrenia research. 2009; 108(1-3): 170-5.

Karlsgodt Katherine H, Sanz Jacqueline, van Erp Theo G M, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia.. Schizophrenia research. 2009; 108(1-3): 143-50.

Kathleen Holmes M, Bearden Carrie E, Barguil Marcela, Fonseca Manoela, Serap Monkul E, Nery Fabiano G, Soares Jair C, Mintz Jim, Glahn David C Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse.. Bipolar disorders. 2009; 11(1): 33-40.

O'Brien Mary P, Zinberg Jamie L, Ho Lorena, Rudd Alexandra, Kopelowicz Alex, Daley Melita, Bearden Carrie E, Cannon Tyrone D Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal study.. Schizophrenia research. 2009; 107(2-3): 198-205.

Bearden Carrie E, Jasinska Anna J, Freimer Nelson B Methodological issues in molecular genetic studies of mental disorders.. Annual review of clinical psychology. 2009; 5(2-3): 49-69.

Bearden Carrie E, van Erp Theo G M, Dutton Rebecca A, Lee Agatha D, Simon Tony J, Cannon Tyrone D, Emanuel Beverly S, McDonald-McGinn Donna, Zackai Elaine H, Thompson Paul M Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions.. Cerebral cortex (New York, N.Y. : 1991). 2009; 19(1): 115-26.

Robinson Jennifer L, Monkul E Serap, Tordesillas-Gutiérrez Diana, Franklin Crystal, Bearden Carrie E, Fox Peter T, Glahn David C Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation.. Psychiatry research. 2008; 164(2): 106-13.

Willhite Rachael K, Niendam Tara A, Bearden Carrie E, Zinberg Jamie, O'Brien Mary P, Cannon Tyrone D Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorder.. Schizophrenia research. 2008; 104(1-3): 237-45.

Bearden Carrie E, Glahn David C, Lee Agatha D, Chiang Ming-Chang, van Erp Theo G M, Cannon Tyrone D, Reiss Allan L, Toga Arthur W, Thompson Paul M Neural phenotypes of common and rare genetic variants.. Biological psychology. 2008; 79(1): 43-57.

Bearden Carrie E, Soares Jair C, Klunder Andrea D, Nicoletti Mark, Dierschke Nicole, Hayashi Kiralee M, Narr Katherine L, Brambilla Paolo, Sassi Roberto B, Axelson David, Ryan Neal, Birmaher Boris, Thompson Paul M Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder.. Journal of the American Academy of Child and Adolescent Psychiatry. 2008; 47(5): 515-25.

Bearden Carrie E, Thompson Paul M, Dutton Rebecca A, Frey Benício N, Peluso Marco A M, Nicoletti Mark, Dierschke Nicole, Hayashi Kiralee M, Klunder Andrea D, Glahn David C, Brambilla Paolo, Sassi Roberto B, Mallinger Alan G, Soares Jair C Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008; 33(6): 1229-38.

Karlsgodt Katherine H, van Erp Theo G M, Poldrack Russell A, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia.. Biological psychiatry. 2008; 63(5): 512-8.

van Erp Theo G M, Lesh Tyler A, Knowlton Barbara J, Bearden Carrie E, Hardt Molly, Karlsgodt Katherine H, Shirinyan David, Rao Vikas, Green Michael F, Subotnik Kenneth L, Nuechterlein Keith, Cannon Tyrone D Remember and know judgments during recognition in chronic schizophrenia.. Schizophrenia research. 2008; 100(1-3): 181-90.

Altshuler Lori L, Bearden Carrie E, Green Michael F, van Gorp Wilfred, Mintz Jim A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study.. Psychiatry research. 2008; 157(1-3): 289-93.

Glahn David C, Bearden Carrie E, Barguil Marcela, Barrett Jennifer, Reichenberg Abraham, Bowden Charles L, Soares Jair C, Velligan Dawn I The neurocognitive signature of psychotic bipolar disorder.. Biological psychiatry. 2007; 62(8): 910-6.

Bearden Carrie E, van Erp Theo G M, Dutton Rebecca A, Tran Helen, Zimmermann Lara, Sun Daqiang, Geaga Jennifer A, Simon Tony J, Glahn David C, Cannon Tyrone D, Emanuel Beverly S, Toga Arthur W, Thompson Paul M Mapping cortical thickness in children with 22q11.2 deletions.. Cerebral cortex (New York, N.Y. : 1991). 2007; 17(8): 1889-98.

Niendam Tara A, Horwitz Jacqueline, Bearden Carrie E, Cannon Tyrone D Ecological assessment of executive dysfunction in the psychosis prodrome: a pilot study.. Schizophrenia research. 2007; 93(1-3): 350-4.

Bearden Carrie E, Thompson Paul M, Dalwani Manish, Hayashi Kiralee M, Lee Agatha D, Nicoletti Mark, Trakhtenbroit Michael, Glahn David C, Brambilla Paolo, Sassi Roberto B, Mallinger Alan G, Frank Ellen, Kupfer David J, Soares Jair C Greater cortical gray matter density in lithium-treated patients with bipolar disorder.. Biological psychiatry. 2007; 62(1): 7-16.

Bearden Carrie E, van Erp Theo G M, Thompson Paul M, Toga Arthur W, Cannon Tyrone D Cortical mapping of genotype-phenotype relationships in schizophrenia.. Human brain mapping. 2007; 28(6): 519-32.

Bearden Carrie E, Glahn David C, Caetano Sheila, Olvera Rene L, Fonseca Manoela, Najt Pablo, Hunter Kristina, Pliszka Steve R, Soares Jair C Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder.. Bipolar disorders. 2007; 9 Suppl 1(1-3): 145-59.

Cornblatt Barbara A, Auther Andrea M, Niendam Tara, Smith Christopher W, Zinberg Jamie, Bearden Carrie E, Cannon Tyrone D Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia.. Schizophrenia bulletin. 2007; 33(3): 688-702.

Niendam Tara A, Bearden Carrie E, Zinberg Jamie, Johnson Jennifer K, O'Brien Mary, Cannon Tyrone D The course of neurocognition and social functioning in individuals at ultra high risk for psychosis.. Schizophrenia bulletin. 2007; 33(3): 772-81.

Glahn David C, Barrett Jennifer, Bearden Carrie E, Mintz Jim, Green Michael F, Serap Monkul E, Najt Pablo, Soares Jair C, Velligan Dawn I Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia.. Psychological medicine. 2006; 36(8): 1085-95.

Bearden Carrie E, Freimer Nelson B Endophenotypes for psychiatric disorders: ready for primetime?. Trends in genetics : TIG. 2006; 22(6): 306-13.

Bearden Carrie E, Glahn David C, Monkul E Serap, Barrett Jennifer, Najt Pablo, Villarreal Veronica, Soares Jair C Patterns of memory impairment in bipolar disorder and unipolar major depression.. Psychiatry research. 2006; 142(2-3): 139-50.

Glahn David C, Bearden Carrie E, Bowden Charles L, Soares Jair C Reduced educational attainment in bipolar disorder.. Journal of affective disorders. 2006; 92(2-3): 309-12.

Niendam Tara A, Bearden Carrie E, Johnson Jennifer K, McKinley Malin, Loewy Rachel, O'Brien Mary, Nuechterlein Keith H, Green Michael F, Cannon Tyrone D Neurocognitive performance and functional disability in the psychosis prodrome.. Schizophrenia research. 2006; 84(1): 100-11.

Glahn David C, Bearden Carrie E, Cakir Sibel, Barrett Jennifer A, Najt Pablo, Serap Monkul E, Maples Natalie, Velligan Dawn I, Soares Jair C Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis.. Bipolar disorders. 2006; 8(2): 117-23.

Bearden Carrie E, Glahn David C, Monkul E Serap, Barrett Jennifer, Najt Pablo, Kaur Simerjit, Sanches Marsal, Villarreal Veronica, Bowden Charles, Soares Jair C Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features.. Journal of psychiatric research. 2006; 40(1): 47-58.

O'Brien Mary P, Gordon Jamie L, Bearden Carrie E, Lopez Steve R, Kopelowicz Alex, Cannon Tyrone D Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis.. Schizophrenia research. 2006; 81(2-3): 269-75.

Glahn David C, Bearden Carrie E, Caetano Sheila, Fonseca Manoela, Najt Pablo, Hunter Kristina, Pliszka Steve R, Olvera Rene L, Soares Jair C Declarative memory impairment in pediatric bipolar disorder.. Bipolar disorders. 2005; 7(6): 546-54.

Loewy Rachel L, Bearden Carrie E, Johnson Jennifer K, Raine Adrian, Cannon Tyrone D The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes.. Schizophrenia research. 2005; 79(1): 117-25.

Simon Tony J, Bish Joel P, Bearden Carrie E, Ding Lijun, Ferrante Samantha, Nguyen Vy, Gee James C, McDonald-McGinn Donna M, Zackai Elaine H, Emanuel Beverly S A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children.. Development and psychopathology. 2005; 17(3): 753-84.

Meyer Stephanie E, Bearden Carrie E, Lux Sabrina R, Gordon Jamie L, Johnson Jennifer K, O'Brien Mary P, Niendam Tara A, Loewy Rachel L, Ventura Joseph, Cannon Tyrone D The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV.. Journal of child and adolescent psychopharmacology. 2005; 15(3): 434-51.

Najt Pablo, Glahn David, Bearden Carrie E, Hatch John P, Monkul E Serap, Kaur Simerjit, Villarreal Veronica, Bowden Charles, Soares Jair C Attention deficits in bipolar disorder: a comparison based on the Continuous Performance Test.. Neuroscience letters. 2005; 379(2): 122-6.

Glahn David C, Ragland J Daniel, Abramoff Adir, Barrett Jennifer, Laird Angela R, Bearden Carrie E, Velligan Dawn I Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia.. Human brain mapping. 2005; 25(1): 60-9.

Simon Tony J, Bearden Carrie E, Mc-Ginn Donna McDonald, Zackai Elaine Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome.. Cortex; a journal devoted to the study of the nervous system and behavior. 2005; 41(2): 145-55.

Baicy Kate, Bearden Carrie E, Monterosso John, Brody Arthur L, Isaacson Andrew J, London Edythe D Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets.. International review of neurobiology. 2005; 65(1): 117-45.

Bearden Carrie E, Jawad Abbas F, Lynch David R, Monterossso John R, Sokol Set, McDonald-McGinn Donna M, Saitta Sulagna C, Harris Stacy E, Moss Edward, Wang Paul P, Zackai Elaine, Emanuel Beverly S, Simon Tony J Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. 2005; 11(1): 109-17.

Bearden Carrie E, Jawad Abbas F, Lynch David R, Sokol Set, Kanes Steven J, McDonald-McGinn Donna M, Saitta Sulagna C, Harris Stacy E, Moss Edward, Wang Paul P, Zackai Elaine, Emanuel Beverly S, Simon Tony J Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.. The American journal of psychiatry. 2004; 161(9): 1700-2.

Bearden Carrie E, van Erp Theo G M, Monterosso John R, Simon Tony J, Glahn David C, Saleh Peter A, Hill Nicole M, McDonald-McGinn Donna M, Zackai Elaine, Emanuel Beverly S, Cannon Tyrone D Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms.. Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology. 2004; 10(3): 198-206.

Glahn David C, Bearden Carrie E, Niendam Tara A, Escamilla Michael A The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder.. Bipolar disorders. 2004; 6(3): 171-82.

Bearden Carrie E, Reus Victor I, Freimer Nelson B Why genetic investigation of psychiatric disorders is so difficult.. Current opinion in genetics & development. 2004; 14(3): 280-6.

Niendam Tara A, Bearden Carrie E, Rosso Isabelle M, Sanchez Laura E, Hadley Trevor, Nuechterlein Keith H, Cannon Tyrone D A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings.. The American journal of psychiatry. 2003; 160(11): 2060-2.

Cannon Tyrone D, van Erp Theo G M, Bearden Carrie E, Loewy Rachel, Thompson Paul, Toga Arthur W, Huttunen Matti O, Keshavan Matcheri S, Seidman Larry J, Tsuang Ming T Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions.. Schizophrenia bulletin. 2003; 29(4): 653-69.

Bearden Carrie E, Wang Paul P, Simon Tony J Williams syndrome cognitive profile also characterizes Velocardiofacial/DiGeorge syndrome.. American journal of medical genetics. 2002; 114(6): 689-92.

Carrie Bearden

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