Treatment Study for Children and Adolescents with Irritability and Restlessness (Severe Mood Dysregulation)

The Division of Child and Adolescent Psychiatry at UCLA is recruiting participants for a research study of children and teens with a newly recognized condition called Severe Mood Dysregulation (SMD).   SMD is characterized by persistent irritability or moodiness, overarousal (including insomnia, agitation, distractibility, racing thoughts, pressured speech, or intrusiveness), and frequent temper tantrums, emotional “meltdowns,” or aggression.  Participants in the study will receive a comprehensive evaluation.  Individuals found to be eligible will also be invited to participate in a medication study that includes treatment with an ADHD medication and either fluoxetine or placebo.  All evaluations and medications will be provided without charge. 

 To qualify for screening:

  1. Children or adolescent must have significant and frequent problems with irritability or moodiness, overactivity, temper outbursts, and overreactions to emotional stimuli.
  2. Potential participants must be between the ages of 7 – 17 years old.
  3. Symptoms should be severe and be the cause of difficulties in at least one setting (home, school, or with peers).
  4. Participants must not be diagnosed with autism or Asperger’s Disorder.

Contact Information

For more information call 310-825-6170 or email