Publications Associated with the Hatos Center
2020
- μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors.
- Genetic and functional analysis of a Pacific hagfish opioid system.
- Delta opioid receptor activation modulates affective pain and modality-specific pain hypersensitivity associated with chronic neuropathic pain.
- In vivo mapping of a GPCR interactome using knockin mice.
- Opioid dose regimen shapes mesolimbic adaptations.
- Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse.
- Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma.
2019
- Blockade of dopamine D1 receptors in male rats disrupts morphine reward in pain naïve but not in chronic pain states.
- Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome.
- Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.
- Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.
- Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect.
2018
- Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment.
- Evidence and Function Relevance of Native DOR-MOR Heteromers.
- Dissociation between morphine-induced spinal gliosis and analgesic tolerance by ultra-low-dose α2-adrenergic and cannabinoid CB1-receptor antagonists.
2017
- Neuroinflammation-a co-occurring phenomenon linking chronic pain and opioid dependence.
- Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.
- Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking.
- Mu opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.
2016
- Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction (in press)
- Neurochips enable nanoscale devices for high resolution in vivo neurotransmitter sensing
- Nicotine modifies corticostriatal plasticity and amphetamine rewarding behaviors in mice (in press)
- Sustained Suppression of Hyperalgesia during Latent Sensitization by m, d and k-opioid receptors and a2A adrenergic receptors; Role of Constitutive Activity
- Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation.
- Topography of microglial activation in sensory- and affect-related brain regions in chronic pain.
- Neurobiology of opioid dependence in creating addiction vulnerability.
- Molecular Pharmacology of δ-Opioid Receptors.
- Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.
- Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta opioid Receptor Function.
- Mu opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.
- Interacting Cannabinoid and opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.
- BOLD Imaging in Awake Wild-Type and Mu- opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone.
- Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.
- Drug discovery: Designing the ideal opioid .
- Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta opioid Receptor Function.
- Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.
- Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence.
- Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3).
2015
- Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist
- Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine
- Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain
- Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity
- Serotonin states and social anxiety
- Sex- and SERT-associated differences in stimulated serotonin revealed by fast microdialysis
- Perinatal vs. genetic programming of serotonin states associated with anxiety
- Latent sensitization: a model for stress-sensitive chronic pain
- Recent advances on the delta opioid receptor: from trafficking to function
- Controlled DNA patterning by chemical lift-off lithography: matrix matters
- Printable ultrathin metal oxide semiconductor-based conformal biosensors
2014
- Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
- Characterization of a novel model of chronic migraine
- A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
- Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
- δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice
- Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice
- Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two-community-based samples of adolescents
- The redistribution of Drosphila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behavior
- Synergistic effects on dopamine cell death in a Drosphila model of chronic toxin exposure
2013
- Rethinking 5‑HT1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior
- Regulation of mu-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
- Chronic inflammatory injury results in increased coupling of delta opioid receptors tovoltage-gated Ca2+ channels
- The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry
- Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis
- Phasic Mesolimbic Dopamine Release tracks reward seeking during expression of Pavlovian-to-Instrumental Transfer
- Targeted Deletion of the Mouse Alpha2 Nicotinic Acetylcholine receptor Subunit Gene (Chma2) Potentiates Nicotine-Modulated Behaviors
- Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
- Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
- Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster
- Delta Opioid Receptors Regulate Temporoammonic-Activated Feed forward Inhibition to the Mouse CA1 Hippocampus
- Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers
- Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and ß-Arrestin 1 Pathway
2012
- Phasic Mesolimbic Dopamine Signaling Precedes and Predicts Performance of a Self-Initiated Action Sequence Task
- Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells
- Transient Extracellular Glutamate Events in the Basolateral Amygdala Track Reward-Seeking Actions
- A Single Administration of Low-Dose Varenicline Saturatesα4ß2* Nicotinic Acetylcholine Receptors in the Human Brain
- Evidence that Behavioral Phenotypes of Morphine in ß-arr2_/_ Mice Are Due to the Unmasking of JNK Signaling
- In VivoVisualization of Delta Opioid Receptors upon Physiological Activation Uncovers a Distinct Internalization Profile
- Ligand-directed signaling within the opioid receptor family
- Serotonin Uptake Is Largely Mediated by Platelets versus Lymphocytes in Peripheral Blood Cells
- Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi- electrode array microprobe
- From the bottom up: dimensional control and characterization in molecular monolayers
- Virtual reality Cue exposure Therapy for The Treatment of tobacco dependence
2011
- Effect of Bupropion Treatment on Brain Activation induced by Cigarette-Related Cues in Smokers
- Mu-Opioid Receptor Activation in the Basolateral Amygdala Mediates the Learning of Increases But Not Decreases in the Incentive Value of a Food Reward
- Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2
- Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human a-Synuclein
- Effect of Secondhand Smoke on Occupancy of Nicotinic Acetylcholine Receptors in Brain
- Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering
- Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice
- Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling
- Presynaptic Control of Rapid Estrogen Fluctuations in the Songbird Auditory Forebrain
- Manipulation of Cigarette Craving with Transcranial Magnetic Stimulation
- A Putative Vesicular Transporter Expressed in Drosophila Mushroom Bodies that Mediates Sexual Behavior May Define a Neurotransmitter System
2010
- Tyrosine-based Motif Localizes a Drosophila Vesicular Transporter to Synaptic Vesicles in Vivo
- Opioid pharmaceuticals and addiction: The issues, and research directionsseeking solutions
- Ligand-Directed Trafficking of thedelta-Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance
2009
- Opioid receptors: From binding sites to visible molecules in vivo
- Neurokinin 1 Receptors Regulate Morphine-Induced Endocytosis and Desensitization of mu-Opioid Receptors in CNS Neurons
- Delta Receptors Are Required for Full Inhibitory Coupling of mu-Receptors to Voltage-Dependent Ca2+ Channels in Dorsal Root Ganglion Neurons
- Pavlovian conditioning of multiple opioid-like responses in mice
- Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition
- Distinct opioid circuits determine the palatability and the desirability of rewarding events
- Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal
2008
- Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo
- Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice
- A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System
- Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin
2007
- ß-Arrestin2 and c-Src Regulate the Constitutive Activity and Recycling of Mu Opioid Receptors in Dorsal Root Ganglion Neurons
- Enkephalin release promotes homeostatic increases in Constitutively active mu opioid receptors during Morphine withdrawal
2006
- Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine
- NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice
- Constitutively Active Mu Opioid Receptors Mediate the Enhanced Conditioned Aversive Effect of Naloxone in Morphine-Dependent Mice
- Mu opioid receptor-effector coupling and trafficking In dorsal root ganglia neurons
- Immunolocalization of orphanin FQ in rat cochlea
- Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy
- Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice
2005
2004
2003
- Blockade of ventral pallidal opioid receptors induces a conditioned place aversion and attenuates acquisition of cocaine place preference in the rat
- Brain Region-Specific Mechanisms for Acute Morphine-Induced Mitogen-Activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic
- Tolerance and Locomotor Sensitization
2002
2001
- Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor
- Agonist-, Antagonist-, and Inverse Agonist-Regulated Trafficking of the Delta-Opioid Receptor Correlates with, but Does Not Require, G Protein Activation
- Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice
2000
1998
- Opioid Regulation of Pallidal Enkephalin Release:Bimodal Effects of Locally Administered Mu& Delta Opioid Agonists in Freely Moving Rats
- mu-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic Mechanism In Vitro and in the Mammalian Brain
- Repeated heroin administration increases extracellular opioid peptide-like immunoreactivity in the globus pallidus/ventral pallidumof freely moving rats
- ORL-1 and Mu Opioid Receptor Antisera Label Different Fibers in Areas Involved in Pain Processing
1997
- Presynaptic Versus Postsynaptic Localization of m and d Opioid Receptors in Dorsal and Ventral Striatopallidal Pathways
- Functional Analysis of Cloned Opioid Receptors inTransfected Cell Lines
- Orphanin FQ Inhibits Synaptic Transmission and Long-Term Potentiation in Rat Hippocampus
1996
