Publications Associated with the Hatos Center

1996
Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1997
Presynaptic Versus Postsynaptic Localization of m and d Opioid Receptors in Dorsal and Ventral Striatopallidal Pathways
Functional Analysis of Cloned Opioid Receptors in Transfected Cell Lines
Orphanin FQ Inhibits Synaptic Transmission and Long-Term Potentiation in Rat Hippocampus

1998
Opioid Regulation of Pallidal Enkephalin Release:Bimodal Effects of Locally Administered Mu & Delta Opioid Agonists in Freely Moving  Rats
mu-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic Mechanism In Vitro and in the Mammalian Brain
Repeated heroin administration increases extracellular opioid peptide-like immunoreactivity in the globus pallidus/ventral pallidumof freely moving rats
ORL-1 and Mu Opioid Receptor Antisera Label Different Fibers in Areas Involved in Pain Processing

2000
Ligand-Induced Changes in Surface µ-Opioid Receptor Number: Relationship to G Protein Activation?

2001

Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor
Agonist-, Antagonist-, and Inverse Agonist-Regulated Trafficking of the Delta-Opioid Receptor Correlates with, but Does Not Require, G Protein Activation

Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice

2002

Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells

2003

Blockade of ventral pallidal opioid receptors induces a conditioned place aversion and attenuates acquisition of cocaine place preference in the rat
Brain Region-Specific Mechanisms for Acute Morphine-Induced Mitogen-Activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic
Tolerance and Locomotor Sensitization


2004
Secrets of the opium poppy revealed

2005

Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice

2006

Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine
NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice
Constitutively Active Mu Opioid Receptors Mediate the Enhanced Conditioned Aversive Effect of Naloxone in Morphine-Dependent Mice

Mu opioid receptor-effector coupling and trafficking In dorsal root ganglia neurons

Immunolocalization of orphanin FQ in rat cochlea
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy

Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice

2007
ß-Arrestin2 and c-Src Regulate the Constitutive Activity and Recycling of Mu Opioid Receptors in Dorsal Root Ganglion Neurons
Enkephalin release promotes homeostatic increases in Constitutively active mu opioid receptors during Morphine withdrawal

2008
Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo
Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice
A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System
Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

2009
Opioid receptors: From binding sites to visible molecules in vivo
Neurokinin 1 Receptors Regulate Morphine-Induced Endocytosis and Desensitization of mu-Opioid Receptors in CNS Neurons
Delta Receptors Are Required for Full Inhibitory Coupling of mu-Receptors to Voltage-Dependent Ca2+ Channels in Dorsal Root Ganglion Neurons
Pavlovian conditioning of multiple opioid-like responses in mice
Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition
Distinct opioid circuits determine the palatability and the desirability of rewarding events
Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal

2010
Tyrosine-based Motif Localizes a Drosophila Vesicular Transporter to Synaptic Vesicles in Vivo
Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions
Ligand-Directed Trafficking of the delta-Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance

2011
Effect of Bupropion Treatment on Brain Activation induced by Cigarette-Related Cues in Smokers

Mu-Opioid Receptor Activation in the Basolateral Amygdala Mediates the Learning of Increases But Not Decreases in the Incentive Value of a Food Reward
Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2
Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human a-Synuclein
Effect of Secondhand Smoke on Occupancy of Nicotinic Acetylcholine Receptors in Brain
Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering
Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice
Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling
Presynaptic Control of Rapid Estrogen Fluctuations in the Songbird Auditory Forebrain
Manipulation of Cigarette Craving with Transcranial Magnetic Stimulation
A Putative Vesicular Transporter Expressed in Drosophila Mushroom Bodies that Mediates Sexual Behavior May Define a Neurotransmitter System

2012
Phasic Mesolimbic Dopamine Signaling Precedes and Predicts Performance of a Self-Initiated Action Sequence Task
Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells
Transient Extracellular Glutamate Events in the Basolateral Amygdala Track Reward-Seeking Actions
A Single Administration of Low-Dose Varenicline Saturates α 4ß2* Nicotinic Acetylcholine Receptors in the Human Brain

Evidence that Behavioral Phenotypes of Morphine in ß-arr2_/_ Mice Are Due to the Unmasking of JNK Signaling
In Vivo Visualization of Delta Opioid Receptors upon Physiological Activation Uncovers a Distinct Internalization Profile
Ligand-directed signaling within the opioid receptor family
Serotonin Uptake Is Largely Mediated by Platelets versus Lymphocytes in Peripheral Blood Cells
Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi- electrode array microprobe
From the bottom up: dimensional control and characterization in molecular monolayers
Virtual reality Cue exposure Therapy for The Treatment of tobacco dependence

2013
Rethinking 5HT1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior
Regulation of mu-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels
The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry
Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis
Phasic Mesolimbic Dopamine Release tracks reward seeking during expression of Pavlovian-to-Instrumental Transfer
Targeted Deletion of the Mouse Alpha2 Nicotinic Acetylcholine receptor Subunit Gene (Chma2) Potentiates Nicotine-Modulated Behaviors
Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster
Delta Opioid Receptors Regulate Temporoammonic-Activated Feed forward Inhibition to the Mouse CA1 Hippocampus
Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers
Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and ß-Arrestin 1 Pathway

2014
Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Characterization of a novel model of chronic migraine
 A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice
Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice
Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two-community-based samples of adolescents
The redistribution of Drosphila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behavior
Synergistic effects on dopamine cell death in a Drosphila model of chronic toxin exposure

2015
Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist
Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine
Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain
Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity
Serotonin states and social anxiety
Sex- and SERT-associated differences in stimulated serotonin revealed by fast microdialysis
Perinatal vs. genetic programming of serotonin states associated with anxiety
Latent sensitization: a model for stress-sensitive chronic pain
Recent advances on the delta opioid receptor: from trafficking to function
Controlled DNA patterning by chemical lift-off lithography: matrix matters
Printable ultrathin metal oxide semiconductor-based conformal biosensors

2016
Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction (in press)
Neurochips enable nanoscale devices for high resolution in vivo neurotransmitter sensing
Nicotine modifies corticostriatal plasticity and amphetamine rewarding behaviors in mice (in press)
Sustained Suppression of Hyperalgesia during Latent Sensitization by m, d and k-opioid receptors and a2A adrenergic receptors; Role of Constitutive Activity