Publications

2020

In vivo mapping of a GPCR interactome using knock-in mice. Proceedings of the National Academy of Science USA, May 26:201917906. PMID: 32457152
Nerve injury-induced changes in delta opioid receptor function and trafficking. Journal of Neuroscience Research Jul 5. doi: 10.1002/jnr.24680. PMID 32623788
Genetic and functional analysis of a Pacific Hagfish opioid system. Journal of Neuroscience Research Aug. 23. doi: 10.1002/jnr.24682. PMID 32830380
Oxycodone in the opioid epidemic: high 'liking', 'wanting', and abuse liability potentially mediated by a new molecular mechanism of action. Cellular and Molecular Neurobiology (in press)
Mu opioid receptors on distinct neuronal populations mediate different aspects of opioid reward-related behaviors. eNeuro Sep 21;7(5):ENEURO.0146-20.2020. doi: 10.1523/ENEURO.0146-20.2020. PMID 32859725
Pain catastrophizing predicts alcohol craving in heavy drinkers independent of pain intensity. Drug and Alcohol Dependence. Oct 20:108368. doi: 10.1016/j.drugalcdep.2020.108368. PMID: 33143942
Insights into the Neurobiology of Craving in Opioid Use Disorder. (in press)

2019

Non-nociceptive Roles of Opioids in the CNS: Opioids Effects on Neurogenesis, Learning/Memory and Affect. Nature Reviews Neuroscience, Jan;20(1):5-18. PMID: 30518959
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain. Journal of Neuroscience Mar 12. pii: 0274-19. PMID: 30862664 * Editor pick for Pain Research Forum
Pain-induced Negative Affect is Mediated via Recruitment of the Nucleus Accumbens Kappa Opioid System. Neuron Mar 4. pii: S0896-6273(19)30164-3. PMID: 30878290
Blockade of Dopamine D1 receptors in male rats disrupts morphine reward in pain naïve but not chronic pain states. Journal of Neuroscience Research Nov 12. doi: 10.1002/jnr.24553. PMID 31721270

2018

Chronic systemic administration of ultra-low dose α2-adrenergic antagonists enhance morphine analgesia and attenuate the development of tolerance following nerve injury. Behavioral Pharmacology Apr;29(2 and 3 - Special Issue):241-254. PMID 29481424.
Fentanyl: Receptor Pharmacology, Abuse Potential, and Implications for Treatment. Neuroscience and Behavioral Reviews. Dec 5. pii: S0149-7634(18)30207-0. PMID: 30528374, PMC7233332

2017

Neuroinflammation - A co-occurring phenomenon linking chronic pain and opioid dependence. Current Opinion in Behavioral Sciences. 13:171-177. PMID 28451629.
Topography of microglial activation in sensory and affect related brain regions in chronic pain. Journal of Neuroscience Research Jun;95(6):1330-1335. PMID: 27574286
Blocking microglial pannexin-1 channels alleviates morphine withdrawal. Nature Medicine. 23(3):355-360. PMID: 28134928

2016

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine. Neuropsychopharmacology Mar;41(4):949-59. PMID: 26202104
Midbrain dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction. Pain. Jan 19. 157(6):1194-8. PMID: 26797678 * Editors Choice.
Neurobiology of opioid dependence in creating addiction vulnerability. F1000Research 5:1748. PMID: 27508068
Molecular Pharmacology of Delta opioid receptors. Pharmacological Reviews. 68(3):631-700. PMID: 27343248, * recognized by F1000Prime
Opioid Tolerance: Mechanisms of activity modulation beyond desensitization and downregulation. Trends in Pharmacological Sciences. Nov;37(11):963-976. PMID: 27670390.

2015

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist. British Journal of Pharmacology. Jan 172(2):691-703. PMID: 24923251
Beyond a Simple Anesthetic Effect: Lidocaine in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome. Urology. May;85(5):1025-1033. PMID: 25917728
Pain and poppies: the good, the bad, and the ugly of opioid analgesics. Journal of Neuroscience 35(41): 13879-88. PMID: 26468188
Microglia Disrupt Reward Circuitry in Chronic Pain. Journal of Neuroscience. 35(22):8442-50. PMID: 26041913