Abnormal Cortical Thickness Alterations in Fetal Alcohol Spectrum Disorders and Their Relationships with Facial Dysmorphology

TitleAbnormal Cortical Thickness Alterations in Fetal Alcohol Spectrum Disorders and Their Relationships with Facial Dysmorphology
Publication TypeJournal Article
Year of Publication2011
AuthorsO'Connor, M
Refereed DesignationRefereed
JournalCerebral Cortex Advance Access
VolumeNA
Start PageNA
IssueNA
Date Published2011
KeywordsCortical thickness, Developmental, fetal alcohol exposure, MRI
Abstract

Accumulating evidence from structural brain imaging studies on individuals with fetal alcohol spectrum disorder (FASD) has
supported links between prenatal alcohol exposure and brain morphological deficits. Although global and regional volumetric reductions appear relatively robust, the effects of alcohol exposure on cortical thickness and relationships with facial dysmorphology are not yet known. The structural magnetic resonance imaging data from 69 children and adolescents with FASD and 58 nonexposed controls collected from 3 sites were examined using FreeSurfer to detect cortical thickness changes across the entire brain in FASD and their associations with facial dysmorphology. Controlling for brain size, subjects with FASD showed significantly thicker cortices than controls in several frontal, temporal, and parietal
regions. Analyses conducted within site further revealed prominent group differences in left inferior frontal cortex within all 3 sites. In addition, increased inferior frontal thickness was significantly correlated with reduced palpebral fissure length. Consistent with previous reports, findings of this study are supportive of regional increases in cortical thickness serving as a biomarker for disrupted brain development in FASD. Furthermore, the significant associations between thickness and dysmorphic measures suggest that the severity of brain anomalies may be reflected by that of the face.

URLhttp://cercor.oxfordjournals.org/content/early/2011/07/28/cercor.bhr193.full.pdf+html