"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy."
Science Translational Medicine
2018
"Striking cessation of cataplexy by opioids."
J Sleep Res
2018
"Interactions of the histamine and hypocretin systems in CNS disorders."
Nat Rev Neurol
2015
"Cataplexy--clinical aspects, pathophysiology and management strategy."
Nat Rev Neurol
2014
"Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance."
J Neurochem
2014
"Greatly increased numbers of histamine cells in human narcolepsy with cataplexy."
Ann Neurol
2013
"Coexistence of narcolepsy and Alzheimer's disease."
Neurobiol Aging
2012
"Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level."
J Neurosci
2011
"Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy."
J Neurosci
2011
"A consensus definition of cataplexy in mouse models of narcolepsy."
Sleep
2009
"Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy."
Sleep
2009
"Hypocretin (orexin) cell loss in Parkinson's disease."
Brain
2007
"Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates."
J Neurosci
2007
"Narcolepsy and the hypocretin system--where motion meets emotion."
Nat Clin Pract Neurol
2006
"Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy."
Neurology
2005
"Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy."
Brain Pathol
2003
"Human narcolepsy is linked to reduced number, size and synaptic bouton density In hypocretin-2 labeled neurons."
Society for Neuroscience
2000
"Narcolepsy"
Scientific American
2000
"Recent developments in narcolepsy research, an explanation for patients and the general public"
Narcolepsy Network Newsletter
2000
"Reduced number of hypocretin neurons in human narcolepsy."
Neuron
2000