Sleep and Inflammation During Adolescence.

TitleSleep and Inflammation During Adolescence.
Publication TypeJournal Article
Year of Publication2016
AuthorsPark H, Tsai KM, Dahl RE, Irwin MR, McCreath H, Seeman TE, Fuligni AJ
JournalPsychosom Med
Date Published2016 Jul-Aug

OBJECTIVE: To investigate the associations between objective and subjective dimensions of adolescent sleep and C-reactive protein (CRP), a key biomarker of inflammation that predicts chronic health problems in adulthood, and whether the associations vary as a function of adolescents' age.

METHODS: A total of 315 adolescents (14.5-18.4 years) wore wrist actigraphs at night to objectively estimate their sleep duration and variability across nights, and completed the Pittsburgh Sleep Quality Index to assess their subjective sleep quality. CRP levels were assayed from dried blood spots obtained from finger pricks. To control for adiposity, age- and sex-specific body mass index percentiles were obtained from height and weight measurements.

RESULTS: Nightly variability in sleep duration was associated with higher levels of CRP (b = 0.13, p = .045). Shorter average sleep duration was associated with higher CRP, but only among younger adolescents (b = -0.11, p = .041). Subjective sleep quality was not associated with CRP.

CONCLUSIONS: The association of sleep with inflammation during adolescence seems more evident in objective dimensions of sleep duration and variability than in the subjective dimensions of sleep quality. Insufficient sleep may be particularly consequential for younger adolescents.

Alternate JournalPsychosom Med
PubMed ID27136501
PubMed Central IDPMC4927381
Grant ListP30 AG017265 / AG / NIA NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
R01 HD062547 / HD / NICHD NIH HHS / United States
R24 HD041022 / HD / NICHD NIH HHS / United States