To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.
Title | To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | O'Connor M-F, Bower JE, Cho HJin, J Creswell D, Dimitrov S, Hamby ME, Hoyt MA, Martin JL, Robles TF, Sloan EK, Thomas KMS, Irwin MR |
Journal | Brain Behav Immun |
Volume | 23 |
Issue | 7 |
Pagination | 887-97 |
Date Published | 2009 Oct |
ISSN | 1090-2139 |
Keywords | Anticholesteremic Agents, Antidepressive Agents, Second-Generation, Antihypertensive Agents, Biomarkers, Body Mass Index, Diet, Epidemiologic Factors, Exercise, Humans, Inflammation, Interleukins, Patient Selection, Physical Fitness, Research Design, Risk Factors, Risk-Taking, Smoking, Social Class, Tumor Necrosis Factor-alpha |
Abstract | Behavioral scientists have increasingly included inflammatory biology as mechanisms in their investigation of psychosocial dynamics on the pathobiology of disease. However, a lack of standardization of inclusion and exclusion criteria and assessment of relevant control variables impacts the interpretation of these studies. The present paper reviews and discusses human biobehavioral factors that can affect the measurement of circulating markers of inflammation. Keywords relevant to inflammatory biology and biobehavioral factors were searched through PubMed. Age, sex, and hormonal status, socioeconomic status, ethnicity and race, body mass index, exercise, diet, caffeine, smoking, alcohol, sleep disruption, antidepressants, aspirin, and medications for cardiovascular disease are all reviewed. A tiered set of recommendations as to whether each variable should be assessed, controlled for, or used as an exclusion criteria is provided. These recommendations provide a framework for observational and intervention studies investigating linkages between psychosocial and behavioral factors and inflammation. |
DOI | 10.1016/j.bbi.2009.04.005 |
Alternate Journal | Brain Behav. Immun. |
PubMed ID | 19389469 |
PubMed Central ID | PMC2749909 |
Grant List | K01 AG028404 / AG / NIA NIH HHS / United States K01 AG028404 / AG / NIA NIH HHS / United States K01 AG028404-02 / AG / NIA NIH HHS / United States K23 AG028452 / AG / NIA NIH HHS / United States K23 AG028452 / AG / NIA NIH HHS / United States K23 AG028452-02 / AG / NIA NIH HHS / United States M01 RR000865 / RR / NCRR NIH HHS / United States M01 RR000865-358141 / RR / NCRR NIH HHS / United States P30 AG028748 / AG / NIA NIH HHS / United States P30 AG028748-049004 / AG / NIA NIH HHS / United States R01 AG026364 / AG / NIA NIH HHS / United States R01 AG026364-05 / AG / NIA NIH HHS / United States R01 AG034588 / AG / NIA NIH HHS / United States R01 CA119159 / CA / NCI NIH HHS / United States R01 CA119159-04 / CA / NCI NIH HHS / United States R01 HL079955 / HL / NHLBI NIH HHS / United States R01 HL079955-04 / HL / NHLBI NIH HHS / United States T32 MH018399 / MH / NIMH NIH HHS / United States T32 MH018399-15 / MH / NIMH NIH HHS / United States T32 MH019925 / MH / NIMH NIH HHS / United States T32 MH019925-11 / MH / NIMH NIH HHS / United States T32 MH019925-12 / MH / NIMH NIH HHS / United States T32-MH19925 / MH / NIMH NIH HHS / United States |