To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.

TitleTo assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.
Publication TypeJournal Article
Year of Publication2009
AuthorsO'Connor M-F, Bower JE, Cho HJin, J Creswell D, Dimitrov S, Hamby ME, Hoyt MA, Martin JL, Robles TF, Sloan EK, Thomas KMS, Irwin MR
JournalBrain Behav Immun
Volume23
Issue7
Pagination887-97
Date Published2009 Oct
ISSN1090-2139
KeywordsAnticholesteremic Agents, Antidepressive Agents, Second-Generation, Antihypertensive Agents, Biomarkers, Body Mass Index, Diet, Epidemiologic Factors, Exercise, Humans, Inflammation, Interleukins, Patient Selection, Physical Fitness, Research Design, Risk Factors, Risk-Taking, Smoking, Social Class, Tumor Necrosis Factor-alpha
Abstract

Behavioral scientists have increasingly included inflammatory biology as mechanisms in their investigation of psychosocial dynamics on the pathobiology of disease. However, a lack of standardization of inclusion and exclusion criteria and assessment of relevant control variables impacts the interpretation of these studies. The present paper reviews and discusses human biobehavioral factors that can affect the measurement of circulating markers of inflammation. Keywords relevant to inflammatory biology and biobehavioral factors were searched through PubMed. Age, sex, and hormonal status, socioeconomic status, ethnicity and race, body mass index, exercise, diet, caffeine, smoking, alcohol, sleep disruption, antidepressants, aspirin, and medications for cardiovascular disease are all reviewed. A tiered set of recommendations as to whether each variable should be assessed, controlled for, or used as an exclusion criteria is provided. These recommendations provide a framework for observational and intervention studies investigating linkages between psychosocial and behavioral factors and inflammation.

DOI10.1016/j.bbi.2009.04.005
Alternate JournalBrain Behav. Immun.
PubMed ID19389469
PubMed Central IDPMC2749909
Grant ListK01 AG028404 / AG / NIA NIH HHS / United States
K01 AG028404 / AG / NIA NIH HHS / United States
K01 AG028404-02 / AG / NIA NIH HHS / United States
K23 AG028452 / AG / NIA NIH HHS / United States
K23 AG028452 / AG / NIA NIH HHS / United States
K23 AG028452-02 / AG / NIA NIH HHS / United States
M01 RR000865 / RR / NCRR NIH HHS / United States
M01 RR000865-358141 / RR / NCRR NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
P30 AG028748-049004 / AG / NIA NIH HHS / United States
R01 AG026364 / AG / NIA NIH HHS / United States
R01 AG026364-05 / AG / NIA NIH HHS / United States
R01 AG034588 / AG / NIA NIH HHS / United States
R01 CA119159 / CA / NCI NIH HHS / United States
R01 CA119159-04 / CA / NCI NIH HHS / United States
R01 HL079955 / HL / NHLBI NIH HHS / United States
R01 HL079955-04 / HL / NHLBI NIH HHS / United States
T32 MH018399 / MH / NIMH NIH HHS / United States
T32 MH018399-15 / MH / NIMH NIH HHS / United States
T32 MH019925 / MH / NIMH NIH HHS / United States
T32 MH019925-11 / MH / NIMH NIH HHS / United States
T32 MH019925-12 / MH / NIMH NIH HHS / United States
T32-MH19925 / MH / NIMH NIH HHS / United States