Publications

A complete list of publications is here

 

 

Preprints

Pribadi, M., Yang, Z., Kim, T. S., Swartz, E. W., Huang, A. Y., Chen, J. A., … Coppola, G. (2016, January 1). CRISPR-Cas9 targeted deletion of the C9orf72 repeat expansion mutation corrects cellular phenotypes in patient-derived iPS cells. bioRxiv. https://doi.org/10.1101/051193 

Huang, A. Y., Yu, D., Davis, L. K., Sul, J.-H., Tsetsos, F., Ramensky, V., … TSAICG/GGRI. (2016, January 1). Rare copy number variants in NRXN1 and CNTN6 increase risk for Tourette syndrome. bioRxiv. https://doi.org/10.1101/062471 

 

2017

Lopez, A., Lee, S. E., Wojta, K., Ramos, E. M., Klein, E., Chen, J., … Rubinsztein, D. C. (2017). A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain: A Journal of Neurology. https://doi.org/10.1093/brain/awx005 

Willsey, A. J., Fernandez, T. V., Yu, D., King, R. A., Dietrich, A., Xing, J., … Heiman, G. A. (2017). De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron, 94(3), 486–499.e9. https://doi.org/10.1016/j.neuron.2017.04.024 

Steele, N. Z. R., Carr, J. S., Bonham, L. W., Geier, E. G., Damotte, V., Miller, Z. A., … Yokoyama, J. S. (2017). Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Medicine, 14(3), e1002272. https://doi.org/10.1371/journal.pmed.1002272 

Fong, J. C., Rojas, J. C., Bang, J., Legati, A., Rankin, K. P., Forner, S., … Geschwind, M. D. (2017). Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy. Journal of Alzheimer’s Disease: JAD, 55(1), 249–258. https://doi.org/10.3233/JAD-160300 

Chen, J., Yu, J.-T., Wojta, K., Wang, H.-F., Zetterberg, H., Blennow, K., … Alzheimer’s Disease Neuroimaging Initiative. (2017). Genome-wide association study identifies MAPT locus influencing human plasma tau levels. Neurology. https://doi.org/10.1212/WNL.0000000000003615

Bonham, L. W., Sirkis, D. W., Fan, J., Aparicio, R. E., Tse, M., Ramos, E. M., … Yokoyama, J. S. (2017). Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer’s disease. Neurocase, 23(1), 65–69. https://doi.org/10.1080/13554794.2017.1294182

Chen, P. B., Kawaguchi, R., Blum, C., Achiro, J. M., Coppola, G., O’Dell, T. J., & Martin, K. C. (2017). Mapping Gene Expression in Excitatory Neurons during Hippocampal Late-Phase Long-Term Potentiation. Frontiers in Molecular Neuroscience, 10, 39. https://doi.org/10.3389/fnmol.2017.00039

Lee, S. E., Sias, A. C., Mandelli, M. L., Brown, J. A., Brown, A. B., Khazenzon, A. M., … Seeley, W. W. (2017). Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers. NeuroImage. Clinical, 14, 286–297. https://doi.org/10.1016/j.nicl.2016.12.006

Fernández-Fournier, M., Perry, D. C., Tartaglia, M. C., de May, M., Boxer, A., Coppola, G., … Geschwind, M. D. (2017). Precipitous Deterioration of Motor Function, Cognition, and Behavior. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2016.6159

Liu, C. Y., Ohki, Y., Tomita, T., Osawa, S., Reed, B. R., Jagust, W., … Ringman, J. M. (2017). Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer’s Disease. Journal of Alzheimer’s Disease: JAD. https://doi.org/10.3233/JAD-161203

 

2016

Naasan, G., Rabinovici, G. D., Ghosh, P., Elofson, J. D., Miller, B. L., Coppola, G., … Rosen, H. J. (2016). Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase, 22(1), 76–83. https://doi.org/10.1080/13554794.2015.1046458

Swartz, E. W., Baek, J., Pribadi, M., Wojta, K. J., Almeida, S., Karydas, A., … Coppola, G. (2016). A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes. Stem Cells Translational Medicine. https://doi.org/10.5966/sctm.2015-0340

Wendelken, L. A., Jahanshad, N., Rosen, H. J., Busovaca, E., Allen, I., Coppola, G., … Valcour, V. (2016). ApoE ε4 is Associated with Cognition, Brain Integrity and Atrophy in HIV Over Age 60. Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/QAI.0000000000001091

Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., … Sofroniew, M. V. (2016). Astrocyte scar formation aids central nervous system axon regeneration. Nature, 532(7598), 195–200. https://doi.org/10.1038/nature17623

Chandran, V., Coppola, G., Nawabi, H., Omura, T., Versano, R., Huebner, E. A., … Geschwind, D. H. (2016). A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron, 89(5), 956–970. https://doi.org/10.1016/j.neuron.2016.01.034

Watson, A., Pribadi, M., Chowdari, K., Clifton, S., Joel Wood, Miller, B. L., … Nimgaonkar, V. (2016). C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis. Psychiatry Research, 235, 200–202. https://doi.org/10.1016/j.psychres.2015.12.007

Schroeder, A. M., Wang, H. B., Park, S., Jordan, M. C., Gao, F., Coppola, G., … Colwell, C. S. (2016). Cardiac Dysfunction in the BACHD Mouse Model of Huntington’s Disease. PloS One, 11(1), e0147269. https://doi.org/10.1371/journal.pone.0147269

Peterson, C. B., Service, S. K., Jasinska, A. J., Gao, F., Zelaya, I., Teshiba, T. M., … Sabatti, C. (2016). Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder. PLoS Genetics, 12(5), e1006046. https://doi.org/10.1371/journal.pgen.1006046

Paul, S., Pflieger, L., Dansithong, W., Figueroa, K. P., Gao, F., Coppola, G., & Pulst, S. M. (2016). Co-expression networks in generation of induced pluripotent stem cells. Biology Open. https://doi.org/10.1242/bio.016402

Ramirez, L. M., Goukasian, N., Porat, S., Hwang, K. S., Eastman, J. A., Hurtz, S., … Apostolova, L. G. (2016). Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy. Neurobiology of Aging, 39, 82–89. https://doi.org/10.1016/j.neurobiolaging.2015.10.037

Touma, M., Kang, X., Zhao, Y., Cass, A. A., Gao, F., Biniwale, R., … Wang, Y. (2016). Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery. Circulation. Cardiovascular Genetics, 9(5), 395–407. https://doi.org/10.1161/CIRCGENETICS.115.001363

Yamin, G., Coppola, G., & Teplow, D. B. (2016). Design, Characterization, and Use of a Novel Amyloid β-Protein Control for Assembly, Neurotoxicity, and Gene Expression Studies. Biochemistry, 55(36), 5049–5060. https://doi.org/10.1021/acs.biochem.6b00579

Ahuja, U., Shokeen, B., Cheng, N., Cho, Y., Blum, C., Coppola, G., & Miller, J. F. (2016). Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor. Proceedings of the National Academy of Sciences of the United States of America, 113(9), 2341–2348. https://doi.org/10.1073/pnas.1600320113

Ranasinghe, K. G., Rankin, K. P., Pressman, P. S., Perry, D. C., Lobach, I. V., Seeley, W. W., … Miller, B. L. (2016). Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2016.2016

Sha, S. J., Khazenzon, A. M., Ghosh, P. M., Rankin, K. P., Pribadi, M., Coppola, G., … Lee, S. E. (2016). Early-onset Alzheimer’s disease versus frontotemporal dementia: resolution with genetic diagnoses? Neurocase, 22(2), 161–167. https://doi.org/10.1080/13554794.2015.1080283

Wang, X., Hao, L., Saur, T., Joyal, K., Zhao, Y., Zhai, D., … Buttner, E. A. (2016). Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes. Frontiers in Molecular Neuroscience, 9, 113. https://doi.org/10.3389/fnmol.2016.00113

Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., … Haggarty, S. J. (2016). Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2016.08.001

Horvath, S., Langfelder, P., Kwak, S., Aaronson, J., Rosinski, J., Vogt, T. F., … Yang, X. W. (2016). Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels. Aging, 8(7), 1485–1512. https://doi.org/10.18632/aging.101005

Crisman, T. J., Zelaya, I., Laks, D. R., Zhao, Y., Kawaguchi, R., Gao, F., … Coppola, G. (2016). Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. PloS One, 11(11), e0164649. https://doi.org/10.1371/journal.pone.0164649

Vossel, K. A., Ranasinghe, K. G., Beagle, A. J., Mizuiri, D., Honma, S. M., Dowling, A. F., … Nagarajan, S. S. (2016). Incidence and Impact of Subclinical Epileptiform Activity in Alzheimer’s Disease. Annals of Neurology. https://doi.org/10.1002/ana.24794

Miller, Z. A., Sturm, V. E., Camsari, G. B., Karydas, A., Yokoyama, J. S., Grinberg, L. T., … Miller, B. L. (2016). Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture. Neurology(R) Neuroimmunology & Neuroinflammation, 3(6), e301. https://doi.org/10.1212/NXI.0000000000000301

Laks, D. R., Ta, L., Crisman, T. J., Gao, F., Coppola, G., Radu, C. G., … Kornblum, H. I. (2016). Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Molecular Cancer Therapeutics, 15(6), 1271–1278. https://doi.org/10.1158/1535-7163.MCT-15-0982

Langfelder, P., Cantle, J. P., Chatzopoulou, D., Wang, N., Gao, F., Al-Ramahi, I., … Yang, X. W. (2016). Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature Neuroscience, 19(4), 623–633. https://doi.org/10.1038/nn.4256

Laks, D. R., Crisman, T. J., Shih, M. Y. S., Mottahedeh, J., Gao, F., Sperry, J., … Kornblum, H. I. (2016). Large-scale assessment of the gliomasphere model system. Neuro-Oncology. https://doi.org/10.1093/neuonc/now045

Ringman, J. M., Monsell, S., Ng, D. W., Zhou, Y., Nguyen, A., Coppola, G., … Vinters, H. V. (2016). Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. Journal of Neuropathology and Experimental Neurology. https://doi.org/10.1093/jnen/nlv028

Srinivasan, R., Lu, T.-Y., Chai, H., Xu, J., Huang, B. S., Golshani, P., … Khakh, B. S. (2016). New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron, 92(6), 1181–1195. https://doi.org/10.1016/j.neuron.2016.11.030

Kozela, E., Juknat, A., Gao, F., Kaushansky, N., Coppola, G., & Vogel, Z. (2016). Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. Journal of Neuroinflammation, 13(1), 136. https://doi.org/10.1186/s12974-016-0603-x

Røsby, O., Legati, A., & Coppola, G. (2016). Primary familial brain calcification in a Norwegian family, caused by a novel SLC20A2 gene mutation. Journal of Neurology. https://doi.org/10.1007/s00415-016-8033-3

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., … Huang, E. J. (2016). Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. https://doi.org/10.1016/j.cell.2016.04.001

Sirkis, D. W., Bonham, L. W., Aparicio, R. E., Geier, E. G., Ramos, E. M., Wang, Q., … Yokoyama, J. S. (2016). Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression. Acta Neuropathologica Communications, 4(1), 98. https://doi.org/10.1186/s40478-016-0367-7

Almeida, S., Gao, F., Coppola, G., & Gao, F.-B. (2016). Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients. Neurobiology of Aging, 42, 35–40. https://doi.org/10.1016/j.neurobiolaging.2016.03.001

Yokoyama, J. S., Marx, G., Brown, J. A., Bonham, L. W., Wang, D., Coppola, G., … Dubal, D. B. (2016). Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging and Behavior, 1–10. https://doi.org/10.1007/s11682-016-9598-2

Karuppagounder, S. S., Alim, I., Khim, S. J., Bourassa, M. W., Sleiman, S. F., John, R., … Ratan, R. R. (2016). Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine, 8(328), 328ra29. https://doi.org/10.1126/scitranslmed.aac6008

Vatsavayai, S. C., Yoon, S. J., Gardner, R. C., Gendron, T. F., Vargas, J. N. S., Trujillo, A., … Seeley, W. W. (2016). Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia. Brain: A Journal of Neurology, aww250. https://doi.org/10.1093/brain/aww250

Hodgson, K., Tansey, K. E., Powell, T. R., Coppola, G., Uher, R., Zvezdana Dernovšek, M., … Dobson, R. (2016). Transcriptomics and the mechanisms of antidepressant efficacy. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 26(1), 105–112. https://doi.org/10.1016/j.euroneuro.2015.10.009

Soosman, S. K., Joseph-Mathurin, N., Braskie, M. N., Bordelon, Y. M., Wharton, D., Casado, M., … Ringman, J. M. (2016). Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiology of Aging, 47, 201–209. https://doi.org/10.1016/j.neurobiolaging.2016.07.030

 

2015

Chen, J. A., Wang, Q., Davis-Turak, J., Li, Y., Karydas, A. M., Hsu, S. C., … Coppola, G. (2015). A Multiancestral Genome-Wide Exome Array Study of Alzheimer Disease, Frontotemporal Dementia, and Progressive Supranuclear Palsy. JAMA Neurology, 90095(4), 414–422. https://doi.org/10.1001/jamaneurol.2014.4040 

Becherel, O. J., Sun, J., Yeo, A. J., Nayler, S., Fogel, B. L., Gao, F., … Lavin, M. F. (2015). A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24(20), 5759–5774. https://doi.org/10.1093/hmg/ddv296 

Moreno, F., Rabinovici, G. D., Karydas, A., Miller, Z., Hsu, S. C., Legati, A., … Grinberg, L. T. (2015). A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques. Acta Neuropathologica Communications, 3(1), 542. https://doi.org/10.1186/s40478-015-0190-6 

Yokoyama, J. S., Lee, A. K. L., Takada, L. T., Busovaca, E., Bonham, L. W., Chao, S. Z., … Rosen, H. J. (2015). Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults [Data set]. (A. C. Naj, Ed.). https://doi.org/10.1371/journal.pone.0118338 

Nicolas, G., Charbonnier, C., de Lemos, R. R., Richard, A.-C., Guillin, O., Wallon, D., … collaborators from the French IBGC study Group. (2015). Brain calcification process and phenotypes according to age and sex: Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriers. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 168(7), 586–594. https://doi.org/10.1002/ajmg.b.32336 

Kozela, E., Juknat, A., Kaushansky, N., Ben-Nun, A., Coppola, G., & Vogel, Z. (2015). Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. Journal of Neuroinflammation, 12(1), 52. https://doi.org/10.1186/s12974-015-0273-0

Shinagawa, S., Naasan, G., Karydas, A. M., Coppola, G., Pribadi, M., Seeley, W. W., … Grinberg, L. T. (2015). Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions. Journal of Geriatric Psychiatry and Neurology, 28(2), 99–107. https://doi.org/10.1177/0891988714554710

Yokoyama, J. S., Bonham, L. W., Sears, R. L., Klein, E., Karydas, A., Kramer, J. H., … Coppola, G. (2015). Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease. BMC Neurology, 15(1), 1349. https://doi.org/10.1186/s12883-015-0304-6

Wagshal, D., Sankaranarayanan, S., Guss, V., Hall, T., Berisha, F., Lobach, I., … Boxer, A. L. (2015). Divergent CSF alterations in two common tauopathies: Alzheimer’s disease and progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 86(3), 244–250. https://doi.org/10.1136/jnnp-2014-308004

Ferrer, I., Legati, A., García-Monco, J. C., Gomez-Beldarrain, M., Carmona, M., Blanco, R., … Coppola, G. (2015). Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy. Journal of Neuropathology and Experimental Neurology, 74(4), 370–379. https://doi.org/10.1097/NEN.0000000000000180

Hayashi, T., Legati, A., Nishikawa, T., & Coppola, G. (2015). First Japanese family with primary familial brain calcification due to a mutation in the PDGFB gene: An exome analysis study : Japanese PFBC family with PDGFB mutation. Psychiatry and Clinical Neurosciences, 69(2), 77–83. https://doi.org/10.1111/pcn.12238

Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., … Carmichael, S. T. (2015). GDF10 is a signal for axonal sprouting and functional recovery after stroke. Nature Neuroscience, 18(12), 1737–1745. https://doi.org/10.1038/nn.4146

Ring, K. L., An, M. C., Zhang, N., O’Brien, R. N., Ramos, E. M., Gao, F., … Ellerby, L. M. (2015). Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells. Stem Cell Reports, 5(6), 1023–1038. https://doi.org/10.1016/j.stemcr.2015.11.005

Oguro-Ando, A., Rosensweig, C., Herman, E., Nishimura, Y., Werling, D., Bill, B. R., … Geschwind, D. H. (2015). Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR. Molecular Psychiatry, 20(April), 1069–1078. https://doi.org/10.1038/mp.2014.124

Lehmann, M., Madison, C., Ghosh, P. M., Miller, Z. A., Greicius, M. D., Kramer, J. H., … Rabinovici, G. D. (2015). Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer’s disease variants. Neurobiology of Aging, 36(10), 2678–2686. https://doi.org/10.1016/j.neurobiolaging.2015.06.029

Legati, A., Giovannini, D., Nicolas, G., López-Sánchez, U., Quintáns, B., Oliveira, J. R. M., … Coppola, G. (2015). Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nature Genetics, 47(6), 579–581. https://doi.org/10.1038/ng.3289

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., … Yang, X. W. (2015). N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice. Neuron, 85(4), 726–741. https://doi.org/10.1016/j.neuron.2015.01.008

Chiam, J. T. W., Lunnon, K., Voyle, N., Proitsi, P., Coppola, G., Geschwind, D., … Sattlecker, M. (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer’s Disease. Journal of Alzheimer’s Disease: JAD, 47(3), 741–750. https://doi.org/10.3233/JAD-150289

Raposo, M., Bettencourt, C., Maciel, P., Gao, F., Ramos, A., Kazachkova, N., … Lima, M. (2015). Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease. Movement Disorders: Official Journal of the Movement Disorder Society, 30(7), 968–975. https://doi.org/10.1002/mds.26238

Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M. W., Rojas, L., … Woolf, C. J. (2015). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron, 86(5), 1215–1227. https://doi.org/10.1016/j.neuron.2015.05.005

Cho, S.-H., Chen, J. A., Sayed, F., Ward, M. E., Gao, F., Nguyen, T. A., … Gan, L. (2015). SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1. Journal of Neuroscience, 35(2), 807–818. https://doi.org/10.1523/JNEUROSCI.2939-14.2015

Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J. U., Weng, Y.-L., … Song, H. (2015). Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience, 18(6), 836–843. https://doi.org/10.1038/nn.4008

Yokoyama, J. S., Bonham, L. W., Sturm, V. E., Adhimoolam, B., Karydas, A., Coppola, G., … Rankin, K. P. (2015). The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia. NeuroImage: Clinical, 9, 283–290. https://doi.org/10.1016/j.nicl.2015.07.017

Mesquita, S. D., Ferreira, A. C., Gao, F., Coppola, G., Geschwind, D. H., Sousa, J. C., … Marques, F. (2015). The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease. Brain, Behavior, and Immunity, 49(June), 280–292. https://doi.org/10.1016/j.bbi.2015.06.008

Jalbrzikowski, M., Lazaro, M. T., Gao, F., Huang, A., Chow, C., Geschwind, D. H., … Bearden, C. E. (2015). Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder. PloS One, 10(7), e0132542. https://doi.org/10.1371/journal.pone.0132542

Lemos, R. R., Ramos, E. M., Legati, A., Nicolas, G., Jenkinson, E. M., Livingston, J. H., … Oliveira, J. R. M. (2015). Update and mutational analysis of SLC20A2: a major cause of primary familial brain calcification. Human Mutation, 36(5), 489–495.

Yokoyama, J. S., Sturm, V. E., Bonham, L. W., Klein, E., Arfanakis, K., Yu, L., … Dubal, D. B. (2015). Variation in longevity gene KLOTHO is associated with greater cortical volumes. Annals of Clinical and Translational Neurology, 2(3), 215–230. https://doi.org/10.1002/acn3.161

Lalli, M. A., Bettcher, B. M., Arcila, M. L., Garcia, G., Guzman, C., Madrigal, L., … Kosik, K. S. (2015). Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer’s disease. Molecular Psychiatry. https://doi.org/10.1038/mp.2015.131

Ng, A. S. L., Sias, A. C., Pressman, P. S., Fong, J. C., Karydas, A. M., Zanto, T. P., … Lee, S. E. (2015). Young-onset frontotemporal dementia in a homozygous tau R406W mutation carrier. Annals of Clinical and Translational Neurology, 2(12), 1124–1128. https://doi.org/10.1002/acn3.265

 

2014

Lee, S. E., Khazenzon, A. M., Trujillo, A. J., Guo, C. C., Yokoyama, J. S., Sha, S. J., … Seeley, W. W. (2014). Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion. Brain: A Journal of Neurology, 137(11), 3047–3060. https://doi.org/10.1093/brain/awu248 

Li, Y., Chen, J. A., Sears, R. L., Gao, F., Klein, E. D., Karydas, A., … Coppola, G. (2014). An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy [Data set]. (G. P. Copenhaver, Ed.). https://doi.org/10.1371/journal.pgen.1004211 

Ting, S. K. S., Benzinger, T., Kepe, V., Fagan, A., Coppola, G., Porter, V., … Ringman, J. M. (2014). A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer’s disease in an African-American woman. Journal of Alzheimer’s Disease: JAD, 40(2), 271–275. https://doi.org/10.3233/JAD-131844 

Scherling, C. S., Hall, T., Berisha, F., Klepac, K., Karydas, A., Coppola, G., … Boxer, A. L. (2014). Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration: Neurofilament in FTD. Annals of Neurology, 75(1), 116–126. https://doi.org/10.1002/ana.24052 

Richter, F., Gao, F., Medvedeva, V., Lee, P., Bove, N., Fleming, S. M., … Chesselet, M.-F. (2014). Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons. Neurobiology of Disease, 69, 263–275. https://doi.org/10.1016/j.nbd.2014.05.012

Yokoyama, J. S., Evans, D. S., Coppola, G., Kramer, J. H., Tranah, G. J., & Yaffe, K. (2014). Genetic modifiers of cognitive maintenance among older adults: Cognitive Maintenance GWAS. Human Brain Mapping, 35(9), 4556–4565. https://doi.org/10.1002/hbm.22494

Lehmann, M., Ghosh, P. M., Madison, C., Karydas, A., Coppola, G., O’Neil, J. P., … Rabinovici, G. D. (2014). Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients. Journal of Neurology, Neurosurgery, and Psychiatry, 85(3), 266–273. https://doi.org/10.1136/jnnp-2013-305858

Sleiman, S. F., Olson, D. E., Bourassa, M. W., Karuppagounder, S. S., Zhang, Y.-L., Gale, J., … Ratan, R. R. (2014). Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition. Journal of Neuroscience, 34(43), 14328–14337. https://doi.org/10.1523/JNEUROSCI.1010-14.2014

Dubal, D. B., Yokoyama, J. S., Zhu, L., Broestl, L., Worden, K., Wang, D., … Mucke, L. (2014). Life Extension Factor Klotho Enhances Cognition. Cell Reports, 7(4), 1065–1076. https://doi.org/10.1016/j.celrep.2014.03.076

Fogel, B. L., Cho, E., Wahnich, A., Gao, F., Becherel, O. J., Wang, X., … Coppola, G. (2014). Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2. Human Molecular Genetics, 23(18), 4758–4769. https://doi.org/10.1093/hmg/ddu190

Wright, M. C., Mi, R., Connor, E., Reed, N., Vyas, A., Alspalter, M., … Hoke, A. (2014). Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration. Journal of Neuroscience, 34(5), 1689–1700. https://doi.org/10.1523/JNEUROSCI.3822-13.2014

Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., … Others. (2014). The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, 8(2), 153–182.

Fitten, L. J., Ortiz, F., Fairbanks, L., Bartzokis, G., Lu, P., Klein, E., … Ringman, J. (2014). Younger age of dementia diagnosis in a Hispanic population in southern California: Younger age of dementia diagnosis in Hispanics. International Journal of Geriatric Psychiatry, 29(6), 586–593. https://doi.org/10.1002/gps.4040

 


2013

Lunnon, K., Sattlecker, M., Furney, S. J., Coppola, G., Simmons, A., Proitsi, P., … Hodges, A. (2013). A blood gene expression marker of early Alzheimer’s disease. Journal of Alzheimer’s Disease: JAD, 33(3), 737–53. https://doi.org/10.3233/JAD-2012-121363 

Zabel, M., Schrag, M., Crofton, A., Tung, S., Beaufond, P., Van Ornam, J., … Kirsch, W. M. (2013). A Shift in Microglial β-Amyloid Binding in Alzheimer’s Disease Is Associated with Cerebral Amyloid Angiopathy. Brain Pathology , 23(4), 390–401. 

Judy, M. E., Nakamura, A., Huang, A., Grant, H., McCurdy, H., Weiberth, K. F., … Kao, A. W. (2013). A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants [Data set]. (S. K. Kim, Ed.). https://doi.org/10.1371/journal.pgen.1003714 

van Blitterswijk, M., Baker, M. C., DeJesus-Hernandez, M., Ghidoni, R., Benussi, L., Finger, E., … Rademakers, R. (2013). C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology, 81(15), 1332–1341. https://doi.org/10.1212/WNL.0b013e3182a8250c 

Juknat, A., Pietr, M., Kozela, E., Rimmerman, N., Levy, R., Gao, F., … Vogel, Z. (2013). Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells. PloS One, 8(4), e61462. https://doi.org/10.1371/journal.pone.0061462 

Fogel, B. L., Baker, C., Curnow, A., Perlman, S. L., Geschwind, D. H., & Coppola, G. (2013). Mutations in PDYN are not responsible for multiple system atrophy. Journal of Neurology, 260(3), 927–928. https://doi.org/10.1007/s00415-012-6830-x

Hsu, S. C., Sears, R. L., Lemos, R. R., Quintáns, B., Huang, A., Spiteri, E., … Coppola, G. (2013). Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics, 14(1), 11–22. https://doi.org/10.1007/s10048-012-0349-2

Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., … Oliveira, J. R. M. (2013). Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nature Genetics, 45(9), 1077–1082. https://doi.org/10.1038/ng.2723

Lee, S. E., Tartaglia, M. C., Yener, G., Genç, S., Seeley, W. W., Sanchez-Juan, P., … Miller, B. L. (2013). Neurodegenerative Disease Phenotypes in Carriers of MAPT p.A152T, A Risk Factor for Frontotemporal Dementia Spectrum Disorders and Alzheimer Disease. Alzheimer Disease and Associated Disorders, 27(4), 302–309. https://doi.org/10.1097/WAD.0b013e31828cc357

Perry, D. C., Lehmann, M., Yokoyama, J. S., Karydas, A., Lee, J. J., Coppola, G., … Rabinovici, G. (2013). Progranulin Mutations as Risk Factors for Alzheimer Disease. JAMA Neurology, 70(6), 774. https://doi.org/10.1001/2013.jamaneurol.393

Lee, G. J., Lu, P. H., Medina, L. D., Rodriguez-Agudelo, Y., Melchor, S., Coppola, G., … Ringman, J. M. (2013). Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer’s disease mutations. Journal of Neurology, Neurosurgery, and Psychiatry, 84(2), 154–162. https://doi.org/10.1136/jnnp-2011-302087

Brochier, C., Dennis, G., Rivieccio, M. A., McLaughlin, K., Coppola, G., Ratan, R. R., & Langley, B. (2013). Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons. Journal of Neuroscience, 33(20), 8621–8632. https://doi.org/10.1523/JNEUROSCI.5214-12.2013

Yamada, T., Yang, Y., Huang, J., Coppola, G., Geschwind, D. H., & Bonni, A. (2013). Sumoylated MEF2A Coordinately Eliminates Orphan Presynaptic Sites and Promotes Maturation of Presynaptic Boutons. Journal of Neuroscience, 33(11), 4726–4740. https://doi.org/10.1523/JNEUROSCI.4191-12.2013

Miller, Z. A., Rankin, K. P., Graff-Radford, N. R., Takada, L. T., Sturm, V. E., Cleveland, C. M., … Miller, B. L. (2013). TDP-43 frontotemporal lobar degeneration and autoimmune disease. Journal of Neurology, Neurosurgery, and Psychiatry, 84(9), 956–962. https://doi.org/10.1136/jnnp-2012-304644

Haase, C. M., Saslow, L. R., Bloch, L., Saturn, S. R., Casey, J. J., Seider, B. H., … Levenson, R. W. (2013). The 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time. Emotion , 13(6), 1068.

Dougherty, J. D., Maloney, S. E., Wozniak, D. F., Rieger, M. A., Sonnenblick, L., Coppola, G., … Heintz, N. (2013). The Disruption of Celf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors. Journal of Neuroscience, 33(7), 2732–2753. https://doi.org/10.1523/JNEUROSCI.4762-12.2013

Gyurak, A., Haase, C. M., Sze, J., Goodkind, M. S., Coppola, G., Lane, J., … Levenson, R. W. (2013). The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity. Emotion , 13(1), 25.