Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.

TitleGraph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.
Publication TypeJournal Article
Year of Publication2016
AuthorsArmstrong CC, Moody TD, Feusner JD, McCracken JT, Chang S, Levitt JG, Piacentini JC, O'Neill J
JournalJ Affect Disord
Volume193
Pagination175-84
Date Published2016 Mar 15
ISSN1573-2517
KeywordsAdolescent, Case-Control Studies, Cerebral Cortex, Child, Female, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Obsessive-Compulsive Disorder, Rest
Abstract

BACKGROUND: fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD.

METHODS: Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD.

RESULTS: As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites.

LIMITATIONS: Relatively large node size; relatively small sample size, comorbidities in some patients.

CONCLUSIONS: Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.

DOI10.1016/j.jad.2015.12.071
Alternate JournalJ Affect Disord
PubMed ID26773910
Grant List01MH081864 / MH / NIMH NIH HHS / United States
R01MH085900 / MH / NIMH NIH HHS / United States