Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.
Title | Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Armstrong CC, Moody TD, Feusner JD, McCracken JT, Chang S, Levitt JG, Piacentini JC, O'Neill J |
Journal | J Affect Disord |
Volume | 193 |
Pagination | 175-84 |
Date Published | 2016 Mar 15 |
ISSN | 1573-2517 |
Keywords | Adolescent, Case-Control Studies, Cerebral Cortex, Child, Female, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Obsessive-Compulsive Disorder, Rest |
Abstract | BACKGROUND: fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS: Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. RESULTS: As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites. LIMITATIONS: Relatively large node size; relatively small sample size, comorbidities in some patients. CONCLUSIONS: Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component. |
DOI | 10.1016/j.jad.2015.12.071 |
Alternate Journal | J Affect Disord |
PubMed ID | 26773910 |
Grant List | 01MH081864 / MH / NIMH NIH HHS / United States R01MH085900 / MH / NIMH NIH HHS / United States |