Cortical thickness and brain volumetric analysis in body dysmorphic disorder.

TitleCortical thickness and brain volumetric analysis in body dysmorphic disorder.
Publication TypeJournal Article
Year of Publication2015
AuthorsMadsen SK, Zai A, Pirnia T, Arienzo D, Zhan L, Moody TD, Thompson PM, Feusner JD
JournalPsychiatry Res
Volume232
Issue1
Pagination115-22
Date Published2015 Apr 30
ISSN1872-7123
KeywordsAdolescent, Adult, Body Dysmorphic Disorders, Brain, Female, Gray Matter, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuroimaging, Organ Size, Young Adult
Abstract

Individuals with body dysmorphic disorder (BDD) suffer from preoccupations with perceived defects in physical appearance, causing severe distress and disability. Although BDD affects 1-2% of the population, the neurobiology is not understood. Discrepant results in previous volumetric studies may be due to small sample sizes, and no study has investigated cortical thickness in BDD. The current study is the largest neuroimaging analysis of BDD. Participants included 49 medication-free, right-handed individuals with DSM-IV BDD and 44 healthy controls matched by age, sex, and education. Using high-resolution T1-weighted magnetic resonance imaging, we computed vertex-wise gray matter (GM) thickness on the cortical surface and GM volume using voxel-based morphometry. We also computed volumes in cortical and subcortical regions of interest. In addition to group comparisons, we investigated associations with symptom severity, insight, and anxiety within the BDD group. In BDD, greater anxiety was significantly associated with thinner GM in the left superior temporal cortex and greater GM volume in the right caudate nucleus. There were no significant differences in cortical thickness, GM volume, or volumes in regions of interest between BDD and control subjects. Subtle associations with clinical symptoms may characterize brain morphometric patterns in BDD, rather than large group differences in brain structure.

DOI10.1016/j.pscychresns.2015.02.003
Alternate JournalPsychiatry Res
PubMed ID25797401
PubMed Central IDPMC4404218
Grant ListK23 MH079212 / MH / NIMH NIH HHS / United States
K23MH079212 / MH / NIMH NIH HHS / United States
P41 EB015922 / EB / NIBIB NIH HHS / United States
P41 EB015922 / EB / NIBIB NIH HHS / United States
R01 MH085667 / MH / NIMH NIH HHS / United States
R01 MH085900 / MH / NIMH NIH HHS / United States
R01 MH089722 / MH / NIMH NIH HHS / United States
R01 MH093535 / MH / NIMH NIH HHS / United States
R01 MH094343 / MH / NIMH NIH HHS / United States
R01 MH097268 / MH / NIMH NIH HHS / United States
R01 MH097268 / MH / NIMH NIH HHS / United States
R01MH085900 / MH / NIMH NIH HHS / United States
R01MH093535 / MH / NIMH NIH HHS / United States
U54EB020403 / EB / NIBIB NIH HHS / United States