Semel Institute for Neuroscience and Human Behavior - Eating disorders

Normal, Healthy Adolescents Wanted

Jamie Feusner — Sat, 10 Apr 2010 00:11:30 +0000

Study Detail

Subjects will receive:

* A functional MRI Scan of the Brain

* Psychiatric Evaluation

* Payment for Participation

The UCLA Body Dysmorphic Disorder and Eating Disorder Programs are looking for control subjects to participate in a study on Body Dysmorphic Disorder and Anorexia Nervosa

If you:

* have no history of psychiatric disorders

* are in good physical health

* are not taking any psychiatric medications

* are 13 to 19 years of age

* are right-handed

Study is conducted by Jamie Feusner, M.D.

and Michael Strober, Ph.D.

UCLA Semel Institute of Neuroscience and Human Behavior

For more information call (310) 206-0468 or email jfeusner@mednet.ucla.edu

Project:

Distinct and Common Phenotypes of Anorexia Nervosa and Body Dysmorphic Disorder

Review and Approval

IRB Flyer:

CONTROL_ADOL_13-19.pdf

Renewal Date:

2011, January 6

Body dysmorphic disorder

Are You Concerned About Your Appearance?

Jamie Feusner — Fri, 09 Apr 2010 23:40:07 +0000

Study Detail

If you:

are very concerned that specific features of your appearance look ugly or unattractive

are spending much of your day thinking about your appearance

are avoiding mirrors or spending a lot of time looking in the mirror

have concerns that cause a lot of distress and/or interfere with your schoolwork or social life

YOU MAY HAVE A PSYCHIATRIC CONDITION CALLED BODY DYSMORPHIC DISORDER, AND MAY BE ELIGIBLE TO TAKE PART IN A STUDY THAT IS PROVIDING FREE:

Diagnostic Evaluation

Brain scans: functional Magnetic Resonance Imaging (fMRI)

In addition, you will be paid for your participation.

Study conducted by Jamie Feusner, M.D.

and Michael Strober, Ph.D.

For more information call: (310) 206-4951 or email jfeusner@mednet.ucla.edu

Project:

Distinct and Common Phenotypes of Anorexia Nervosa and Body Dysmorphic Disorder

Review and Approval

IRB Flyer:

BDD_flyer.pdf

Renewal Date:

2011, January 6

Body dysmorphic disorder

Normal, Healthy Adults Wanted

System Admin — Mon, 19 Oct 2009 22:02:25 +0000

Study Detail

NORMAL, HEALTHY ADULTS WANTED

Subjects will receive;

* A functional MRI Scan of the brain

* Psychiatric Evaluation

* Payment for Participation

The UCLA Body Dysmorphic Disorder and Eating Disorder Programs are looking for control subjects to participate in a study on Body Dysmorphic Disorder and Anorexia Nervosa

Project:

Distinct and Common Phenotypes of Anorexia Nervosa and Body Dysmorphic Disorder

More information and application

Pre-conditions:

You may be eligible if you:

have no history of psychiatric disorders
are in good physical health
are not taking any psychiatric medications
are 13 to 64 years of age
are right-handed

Contact details:

Study is conducted by Jamie Feusner, M.D. and Michael Strober, Ph.D.

For more information call (310) 206-0468.

Review and Approval

IRB Flyer:

AN_BDD_color_flyers_09-01-025-01A 3.pdf

Renewal Date:

2010, January 21

Body dysmorphic disorder

Do You Have Anorexia Nervosa

System Admin — Mon, 19 Oct 2009 17:00:30 +0000

Study Detail

DO YOU HAVE ANOREXIA NERVOSA?

The UCLA Eating Disorder and Body Dysmorphic Disorder Programs are looking for people with Anorexia Nervosa to take part in a study that is providing free:

Diagnostic Evaluation
Neurocognitive tests
Brain scans: functional Magnetic Resonance Imaging (fMRI)

In addition, you will be paid for your participation.

Project:

Distinct and Common Phenotypes of Anorexia Nervosa and Body Dysmorphic Disorder

More information and application

Contact details:

Study conducted by Jamie Feusner, M.D. and Michael Strober, Ph.D. Semel Institute for Neuroscience and Human Behavior

For more information call (310) 206-4951

Review and Approval

IRB Flyer:

AN_BDD_color_flyers_09-01-025-01A 5.pdf

Renewal Date:

2010, January 21

Distinct and Common Phenotypes of Anorexia Nervosa and Body Dysmorphic Disorder

System Admin — Mon, 19 Oct 2009 16:37:24 +0000

Project summary

For more information and to see if you qualify for the study, please call 310-206-4951 or email jfeusner@mednet.ucla.edu

The purpose of this study is to characterize shared and unique brain circuits associated with Body Dysmorphic Disorder (BDD) and Anorexia Nervosa (AN) using a set of functional neuroimaging experiments. Body dysmorphic disorder (BDD) and anorexia nervosa (AN) are severe and disabling psychiatric disorders that share many clinical features such as distorted body image, overvaluation of appearance for self-worth, yet they are currently classified in separate diagnostic categories. Despite their significant morbidity and mortality, very little research has been conducted to compare and contrast these disorders in order to understand the underlying neurobiology of shared and unique clinical phenotypes.

An important shared clinical phenotype in BDD and AN is perceptual distortion of appearance, which may contribute to distorted body image. There is early evidence of similar, common phenotypes of disturbances in visual perception and visuospatial processing in BDD and AN, as evidenced clinically and from neuropsychological testing. However, little is known of the underlying neurobiological processes that mediate these. A preliminary functional magnetic resonance imaging (fMRI) study by our group in adults with BDD demonstrated abnormal activation in left hemisphere regions responsible for high-detail processing when viewing others’ faces. A more recent study in BDD demonstrated no abnormalities of primary emotional processing regions when viewing own-faces. AN, on the other hand, is often characterized by early, childhood-onset anxiety in addition to extreme fears of weight gain. However, no study has specifically examined fear processing in AN nor compared it to BDD.

The goal of the proposed study is to define the distinct and common phenotypes of visual and emotional processing in BDD and AN that map onto specific brain systems. This study will enroll 25 medication-free subjects with BDD, 25 with weight-restored AN, and 25 healthy controls. We will study individuals ages 13 to 30, in order to capture those who are the beginning stages of these illnesses. fMRI will be used to identify key abnormalities in brain systems associated with visual and emotional processing. Based on the previous fMRI paradigm in BDD, and other previous studies suggesting abnormalities of detail-processing in AN, this study will investigate visual processing of others’ faces, bodies, and non-face objects (houses) using different types of visual images that convey high, low, or normal level of detail. We are also utilizing eye-tracking to understand how visual search behaviors relate to brain activation patterns. To compare and contrast patterns of emotional processing, this study will use fearful face stimuli to understand common or distinct brain activity patterns associated with emotional reactivity, regulation, and habituation.

There is increasing awareness that our current categorically defined psychiatric disorders lack validity given symptom overlap, longitudinal shifts in symptom expression, and the absence of unique and singular biological markers. Therefore, bridging the study of overlapping disorders is a potential means of identifying shared and dissociable, illness-specific defects in causative mechanisms. A better understanding will help improve classification schemes and guide future research aimed at prevention, recovery, and cure.

For more information and to see if you qualify for the study, please call 310-206-4951 or email jfeusner@mednet.ucla.edu.

Timescale:

05/01/2011 - 12/31/2015

Investigators

Primary Investigator:

Jamie Feusner

Co-Investigators:

Michael Strober

Other Investigators:

Cara Bohon

Body dysmorphic disorder

Eating Disorders Program

Semel Web Manager — Tue, 25 Aug 2009 21:39:34 +0000

UCLA Eating Disorders Program at the Resnick Neuropsychiatric Hospital is dedicated to providing outstanding treatment services tailored to the individual's needs, for children, adolescents and adults with eating disorders. Our multidisciplinary treatment team provides specialized treatment across a continuum of care.

Learn more about our treatment programs:

More information at eatingdisorders.ucla.edu

Partial Hospital Program

Inpatient Hospital Program

Booking

For admission to the adolescent inpatient eating disorders program, please contact Roberta Freeman, R.N., M.S.N., at (310) 267-9140.

For admission to the adult inpatient eating disorders program, please contact Maureen Lynch, R.N., M.S.N., at (310) 267-7364.

For admission to one of the outpatient eating disorders groups, please contact Cynthia Pikus, Ph.D., at (310) 206-3954.

Location

For more parking and transportation information, please visit www.semel.ucla.edu/maps

Site:

Resnick Neuropsychiatric Hospital

Faculty and Staff

Director:

Michael Strober

Director:

Cynthia Pikus

Division of Adult Psychiatry

Adolescent Partial Hospitalization Program

Semel Web Manager — Tue, 25 Aug 2009 18:08:51 +0000

The Adolescent Partial Hospital Program and the Eating Disorder Partial Hospital Program are part of the continuum of care provided by the Adolescent Service within the Resnick Neuropsychiatric Hospital at UCLA. The APHP and the EDPHP offer a time limited, treatment program of therapeutically intensive clinical service and group interventions. For adolescent patients, an academic program is provided on site through the Berenece Carlson Hospital School of LAUSD.

Partial Hospital Program

Booking

Availability:

Mon-Fri 0900-1530

Contact our ACCESS Center at (800) 825-9989 or (310) 825-9989. Service available Monday to Friday, 8 am to 5 pm (PST).

Location

Site:

Resnick Neuropsychiatric Hospital

Division of Child and Adolescent Psychiatry

Body Dysmorphic Disorder Symptoms

System Admin — Thu, 11 Jun 2009 17:04:22 +0000

How do I know if I have body dysmorphic disorder?

Here are questions that might help you decide if you are experiencing symptoms of BDD:

Body dysmorphic disorder

Researchers identify the brain circuits that control hunger

System Admin — Tue, 30 Oct 2007 22:18:14 +0000

Researchers at UCLA have identified the brain circuits involved in hunger that are influenced by the hormone leptin, the signaling molecule produced by fat cells.

Semel Institute for Neuroscience and Human Behavior