Combined fMRI, structural MRI, 18MPPF PET and APOE status to detect AD Risk

This program proposes to use high resolution functional MRI of the hippocampus in combination with critical nfolding techniques, and 18F MPPF PET, a 5HT1a receptor ligand, to identify early changes in hippocampal structure and function in subjects with a genetic risk for Alzheimer’s Disease, possessing a APOE-4 allele.