Publications

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2011
Siegel, JM.  2011.  REM sleep: a biological and psychological paradox.. Sleep medicine reviews. 15(3):139-42.
Wu, M-F, Nienhuis R, Maidment N, Lam HA, Siegel JM.  2011.  Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(17):6305-10. Abstract
2009
Scammell, TE, Willie JT, Guilleminault C, Siegel JM.  2009.  A consensus definition of cataplexy in mouse models of narcolepsy.. Sleep. 32(1):111-6. Abstract
Thannickal, TC, Nienhuis R, Siegel JM.  2009.  Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.. Sleep. 32(8):993-8. Abstract
Thannickal, TC, Nienhuis R, Siegel JM.  2009.  Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy. SLEEP. 32(8) Abstract  Download: 09 narc cataplexy thannickal.pdf (1.33 MB)
2004
John, J, Wu M-F, Maidment NT, Lam HA, Boehmer LN, Patton M, Siegel JM.  2004.  Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers.. The Journal of physiology. 560(Pt 2):587-92. Abstract
John, J, Wu M-F, Boehmer LN, Siegel JM.  2004.  Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior.. Neuron. 42(4):619-34. Abstract
Siegel, JM.  2004.  Hypocretin (Orexin): Role in Normal Behavior and Neuropathology. Annual Review of Psychology. 55 Abstract  Download: Original article (450.13 KB); Figure 3 (PowerPoint Slide) (248 KB)
2001
Kiyashchenko, LI, Mileykovskiy BY, Lai YY, Siegel JM.  2001.  Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area.. Journal of neurophysiology. 85(5):2008-16. Abstract
1998
Reid, MS, Nishino S, Tafti M, Siegel JM, Dement WC, Mignot E.  1998.  Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.. Experimental neurology. 151(1):89-104. Abstract
1996
Reid, MS, Tafti M, Nishino S, Sampathkumaran R, Siegel JM, Mignot E.  1996.  Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine.. Brain research. 733(1):83-100. Abstract
1994
Reid, MS, Tafti M, Nishino S, Siegel JM, Dement WC, Mignot E.  1994.  Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.. Sleep. 17(5):424-35. Abstract
Reid, MS, Tafti M, Geary JN, Nishino S, Siegel JM, Dement WC, Mignot E.  1994.  Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation.. Neuroscience. 59(3):511-22. Abstract
Reid, MS, Siegel JM, Dement WC, Mignot E.  1994.  Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy.. Neuroscience. 59(3):523-30. Abstract
1993
Mignot, E, Nishino S, Sharp LH, Arrigoni J, Siegel JM, Reid MS, Edgar DM, Ciaranello RD, Dement WC.  1993.  Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13(3):1057-64. Abstract
1992
Siegel, JM, Nienhuis R, Fahringer HM, Chiu C, Dement WC, Mignot E, Lufkin R.  1992.  Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 12(5):1640-6. Abstract
1989
Siegel, JM, Tomaszewski KS, Fahringer H, Cave G, Kilduff T, Dement WC.  1989.  Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs.. The American journal of physiology. 256(1 Pt 2):H111-9. Abstract