Publications

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2011
Wu, M-F, Nienhuis R, Maidment N, Lam HA, Siegel JM.  2011.  Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes.. Archives italiennes de biologie. 149(4):492-8. Abstract  Download: 11 hcrt csf exercise wu siegel.pdf (217.84 KB)
2009
Thannickal, TC, Nienhuis R, Siegel JM.  2009.  Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy. SLEEP. 32(8) Abstract  Download: 09 narc cataplexy thannickal.pdf (1.33 MB)
2003
Thannickal, TC, Siegel JM, Nienhuis R, Moore RY.  2003.  Pattern of Hypocretin (Orexin) Soma and Axon Loss, and Gliosis, in Human Narcolepsy. Brain Pathology. 13 Abstract  Download: Original article (1.52 MB)
2000
Thannickal, TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM.  2000.  Reduced number of hypocretin neurons in human narcolepsy.. Neuron. 27(3):469-74. Abstract
Thannickal, TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM.  2000.  Reduced Number of Hypocretin Neurons in Human Narcolepsy. Neuron. 27 Abstract  Download: 469.pdf (306.51 KB)
1999
Siegel, JM, Nienhuis R, Gulyani S, Ouyang S, Wu MF, Mignot E, Switzer RC, McMurry G, Cornford M.  1999.  Neuronal degeneration in canine narcolepsy.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(1):248-57. Abstract
1998
Siegel, JM, Manger PR, Nienhuis R, Fahringer HM, Pettigrew JD.  1998.  Monotremes and the evolution of rapid eye movement sleep.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 353(1372):1147-57. Abstract
1996
Siegel, JM, Manger PR, Nienhuis R, Fahringer HM, Pettigrew JD.  1996.  The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16(10):3500-6. Abstract
1995
Nitz, D, Andersen A, Fahringer H, Nienhuis R, Mignot E, Siegel J.  1995.  Altered distribution of cholinergic cells in the narcoleptic dog.. Neuroreport. 6(11):1521-4. Abstract
1992
Siegel, JM, Nienhuis R, Fahringer HM, Chiu C, Dement WC, Mignot E, Lufkin R.  1992.  Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 12(5):1640-6. Abstract
1991
Siegel, JM, Nienhuis R, Fahringer HM, Paul R, Shiromani P, Dement WC, Mignot E, Chiu C.  1991.  Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.. Science (New York, N.Y.). 252(5010):1315-8. Abstract
1989
Nienhuis, R, Siegel JM.  1989.  Analysis of head movement and position using hall effect devices.. Physiology & behavior. 45(1):199-203. Abstract
1984
Siegel, JM, Nienhuis R, Tomaszewski KS.  1984.  REM sleep signs rostral to chronic transections at the pontomedullary junction.. Neuroscience letters. 45(3):241-6. Abstract
1983
Siegel, JM, Nienhuis R, Tomaszewski KS.  1983.  Rostral brainstem contributes to medullary inhibition of muscle tone.. Brain research. 268(2):344-8. Abstract
1981
Siegel, JM, Nienhuis R, Wheeler RL, McGinty DJ, Harper RM.  1981.  Discharge pattern of reticular formation unit pairs in waking and REM sleep.. Experimental neurology. 74(3):875-91.