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Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(7):1962-76.. 2009.
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.. The Journal of biological chemistry. 283(50):34696-703.. 2008.