Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.

TitleMeta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.
Publication TypeJournal Article
Year of Publication2008
AuthorsZhou, K, Dempfle A, Arcos-Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar J, Castellanos XF, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muenke M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner TJ, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga-Barke E, Steinhausen H-C, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P
JournalAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume147B
Issue8
Pagination1392-8
Date Published2008 Dec 5
ISSN1552-485X
KeywordsAttention Deficit Disorder with Hyperactivity, Chromosome Mapping, Chromosomes, Human, Pair 16, European Continental Ancestry Group, Genetic Linkage, Genome, Human, Humans, Lod Score, Probability
Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.

Alternate JournalAm. J. Med. Genet. B Neuropsychiatr. Genet.