Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice.

TitleEstrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice.
Publication TypeJournal Article
Year of Publication2010
AuthorsYaghmaie, F, Saeed O, Garan SA, Voelker MA, Sternberg H, Timiras PS
JournalNeuro endocrinology letters
Volume31
Issue1
Pagination56-62
Date Published2010
ISSN0172-780X
KeywordsAge Factors, Aging, Animals, Arcuate Nucleus, Cell Count, Estrogen Receptor alpha, Female, hypothalamus, Immunohistochemistry, Mice, Mice, Inbred C57BL
Abstract

Changes in the neuroendocrine regulation of gonadal function, via altered hypothalamic sensitivity to peripheral hormones, are known to schedule reproductive maturation in the young and influence reproductive senescence. Estrogen (E) is a key hormone in this process. While changes in circulating levels of E over the life span are well documented, less is known about the corresponding changes in E sensitivity over the lifespan, especially during middle-age, when the initial signs of reproductive senescence emerge.

DOI10.1038/npp.2012.42
Alternate JournalNeuro Endocrinol. Lett.