Antiretroviral adherence and the nature of HIV-associated verbal memory impairment.
|Title||Antiretroviral adherence and the nature of HIV-associated verbal memory impairment.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Wright, MJ, Woo E, Foley J, Ettenhofer ML, Cottingham ME, Gooding AL, Jang J, Kim MS, Castellon SA, Miller EN, Hinkin CH|
|Journal||The Journal of neuropsychiatry and clinical neurosciences|
|Date Published||2011 Summer|
|Keywords||Adult, Analysis of Variance, Anti-Retroviral Agents, Female, HIV Infections, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Patient Compliance, Regression Analysis, Verbal Learning|
The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer verbal memory than HIV-negative participants. Both good (≥90%) and poor (<90%) adherers displayed encoding deficits as compared with controls, but only poor adherers exhibited retrieval deficits. Encoding deficits primarily accounted for reduced delayed recall in good adherers, but both encoding and retrieval deficits accounted for reduced delayed recall in poor adherers. The retrieval difference between the adherence groups might be explained by a neuroprotective effect of good antiretroviral adherence or preexisting HIV-related retrieval deficits that result in poorer adherence.
|Alternate Journal||J Neuropsychiatry Clin Neurosci|