Antiretroviral adherence and the nature of HIV-associated verbal memory impairment.

TitleAntiretroviral adherence and the nature of HIV-associated verbal memory impairment.
Publication TypeJournal Article
Year of Publication2011
AuthorsWright, MJ, Woo E, Foley J, Ettenhofer ML, Cottingham ME, Gooding AL, Jang J, Kim MS, Castellon SA, Miller EN, Hinkin CH
JournalThe Journal of neuropsychiatry and clinical neurosciences
Volume23
Issue3
Pagination324-31
Date Published2011 Summer
ISSN1545-7222
KeywordsAdult, Analysis of Variance, Anti-Retroviral Agents, Female, HIV Infections, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Patient Compliance, Regression Analysis, Verbal Learning
Abstract

The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer verbal memory than HIV-negative participants. Both good (≥90%) and poor (<90%) adherers displayed encoding deficits as compared with controls, but only poor adherers exhibited retrieval deficits. Encoding deficits primarily accounted for reduced delayed recall in good adherers, but both encoding and retrieval deficits accounted for reduced delayed recall in poor adherers. The retrieval difference between the adherence groups might be explained by a neuroprotective effect of good antiretroviral adherence or preexisting HIV-related retrieval deficits that result in poorer adherence.

DOI10.1111/j.1460-9568.2012.08134.x
Alternate JournalJ Neuropsychiatry Clin Neurosci