Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations.
|Title||Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Wong, K-P, Kepe V, Dahlbom M, Satyamurthy N, Small GW, Barrio JR, Huang S-C|
|Date Published||2012 Mar|
|Keywords||Aged, Alzheimer Disease, Data Interpretation, Statistical, Female, Fluorine Radioisotopes, Humans, Male, Nitriles, Positron-Emission Tomography, Radiopharmaceuticals|
Logan graphical analysis with cerebellum as reference region has been widely used for the estimation of the distribution volume ratio (DVR) of [(18)F]FDDNP as a measure of amyloid burden and tau deposition in human brain because of its simplicity and computational ease. However, spurious parametric DVR images may be produced with shorter scanning times and when the noise level is high. In this work, we have characterized a relative-equilibrium-based (RE) graphical method against the Logan analysis for parametric imaging and region-of-interest (ROI) analysis.