Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations.

TitleComparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations.
Publication TypeJournal Article
Year of Publication2012
AuthorsWong, K-P, Kepe V, Dahlbom M, Satyamurthy N, Small GW, Barrio JR, Huang S-C
JournalNeuroImage
Volume60
Issue1
Pagination241-51
Date Published2012 Mar
ISSN1095-9572
KeywordsAged, Alzheimer Disease, Data Interpretation, Statistical, Female, Fluorine Radioisotopes, Humans, Male, Nitriles, Positron-Emission Tomography, Radiopharmaceuticals
Abstract

Logan graphical analysis with cerebellum as reference region has been widely used for the estimation of the distribution volume ratio (DVR) of [(18)F]FDDNP as a measure of amyloid burden and tau deposition in human brain because of its simplicity and computational ease. However, spurious parametric DVR images may be produced with shorter scanning times and when the noise level is high. In this work, we have characterized a relative-equilibrium-based (RE) graphical method against the Logan analysis for parametric imaging and region-of-interest (ROI) analysis.

Alternate JournalNeuroimage