Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region.
|Title||Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Wong, K-P, Wardak M, Shao W, Dahlbom M, Kepe V, Liu J, Satyamurthy N, Small GW, Barrio JR, Huang S-C|
|Journal||European journal of nuclear medicine and molecular imaging|
|Date Published||2010 Mar|
|Keywords||Aged, Alzheimer Disease, Amyloid, Biological Transport, Brain, Case-Control Studies, Cerebellum, cognition, Discriminant Analysis, Female, Humans, Kinetics, Male, Nitriles, Positron-Emission Tomography, Reference Values, Sensory Receptor Cells|
Subcortical white matter is known to be relatively unaffected by amyloid deposition in Alzheimer's disease (AD). We investigated the use of subcortical white matter as a reference region to quantify [(18)F]FDDNP binding in the human brain.
|Alternate Journal||Eur. J. Nucl. Med. Mol. Imaging|