Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region.

TitleQuantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region.
Publication TypeJournal Article
Year of Publication2010
AuthorsWong, K-P, Wardak M, Shao W, Dahlbom M, Kepe V, Liu J, Satyamurthy N, Small GW, Barrio JR, Huang S-C
JournalEuropean journal of nuclear medicine and molecular imaging
Volume37
Issue3
Pagination575-88
Date Published2010 Mar
ISSN1619-7089
KeywordsAged, Alzheimer Disease, Amyloid, Biological Transport, Brain, Case-Control Studies, Cerebellum, cognition, Discriminant Analysis, Female, Humans, Kinetics, Male, Nitriles, Positron-Emission Tomography, Reference Values, Sensory Receptor Cells
Abstract

Subcortical white matter is known to be relatively unaffected by amyloid deposition in Alzheimer's disease (AD). We investigated the use of subcortical white matter as a reference region to quantify [(18)F]FDDNP binding in the human brain.

Alternate JournalEur. J. Nucl. Med. Mol. Imaging