Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.
|Title||Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Wheat, LA, Haberzettl P, Hellmann J, Baba SP, Bertke M, Lee J, McCracken J, O'Toole TE, Bhatnagar A, Conklin DJ|
|Journal||Arteriosclerosis, thrombosis, and vascular biology|
|Date Published||2011 Jul|
|Keywords||Acrolein, Air Pollutants, Analysis of Variance, Animals, Antigens, Ly, Apoptosis, Bone Marrow Cells, Cell Movement, Cells, Cultured, Endothelial Cells, Heterocyclic Compounds, Inhalation Exposure, Injections, Subcutaneous, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Nitric Oxide, Nitric Oxide Synthase Type III, Phenotype, Phosphorylation, Proto-Oncogene Proteins c-akt, Time Factors, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-2|
Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust. Because exposure to these pollutants is associated with an increase in cardiovascular disease risk, we studied the effects of acrolein on Flk-1(+)/Sca-1(+) cells that are involved in vascular repair.
|Alternate Journal||Arterioscler. Thromb. Vasc. Biol.|