Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.

TitleAcrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.
Publication TypeJournal Article
Year of Publication2011
AuthorsWheat, LA, Haberzettl P, Hellmann J, Baba SP, Bertke M, Lee J, McCracken J, O'Toole TE, Bhatnagar A, Conklin DJ
JournalArteriosclerosis, thrombosis, and vascular biology
Volume31
Issue7
Pagination1598-606
Date Published2011 Jul
ISSN1524-4636
KeywordsAcrolein, Air Pollutants, Analysis of Variance, Animals, Antigens, Ly, Apoptosis, Bone Marrow Cells, Cell Movement, Cells, Cultured, Endothelial Cells, Heterocyclic Compounds, Inhalation Exposure, Injections, Subcutaneous, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Nitric Oxide, Nitric Oxide Synthase Type III, Phenotype, Phosphorylation, Proto-Oncogene Proteins c-akt, Time Factors, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-2
Abstract

Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust. Because exposure to these pollutants is associated with an increase in cardiovascular disease risk, we studied the effects of acrolein on Flk-1(+)/Sca-1(+) cells that are involved in vascular repair.

DOI10.1016/j.brat.2011.06.001
Alternate JournalArterioscler. Thromb. Vasc. Biol.