DISC1: a schizophrenia gene with multiple personalities.
|Title||DISC1: a schizophrenia gene with multiple personalities.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Wexler, EM, Geschwind DH|
|Date Published||2011 Nov 17|
|Keywords||Adaptor Proteins, Signal Transducing, Animals, Brain, Brain Chemistry, Female, Glycogen Synthase Kinase 3, Humans, Male, Nerve Tissue Proteins, Neurogenesis, Polymorphism, Genetic, Pregnancy, Schizophrenia, Signal Transduction, Wnt3A Protein|
Two papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue of Neuron. These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field.