DISC1: a schizophrenia gene with multiple personalities.

TitleDISC1: a schizophrenia gene with multiple personalities.
Publication TypeJournal Article
Year of Publication2011
AuthorsWexler, EM, Geschwind DH
JournalNeuron
Volume72
Issue4
Pagination501-3
Date Published2011 Nov 17
ISSN1097-4199
KeywordsAdaptor Proteins, Signal Transducing, Animals, Brain, Brain Chemistry, Female, Glycogen Synthase Kinase 3, Humans, Male, Nerve Tissue Proteins, Neurogenesis, Polymorphism, Genetic, Pregnancy, Schizophrenia, Signal Transduction, Wnt3A Protein
Abstract

Two papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue of Neuron. These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field.

DOI10.1038/nn.3115
Alternate JournalNeuron