Movement correction method for human brain PET images: application to quantitative analysis of dynamic 18F-FDDNP scans.

TitleMovement correction method for human brain PET images: application to quantitative analysis of dynamic 18F-FDDNP scans.
Publication TypeJournal Article
Year of Publication2010
AuthorsWardak, M, Wong K-P, Shao W, Dahlbom M, Kepe V, Satyamurthy N, Small GW, Barrio JR, Huang S-C
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume51
Issue2
Pagination210-8
Date Published2010 Feb
ISSN1535-5667
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Brain, Case-Control Studies, Female, Fluorine Radioisotopes, Head Movements, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nitriles, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies
Abstract

Head movement during a PET scan (especially a dynamic scan) can affect both the qualitative and the quantitative aspects of an image, making it difficult to accurately interpret the results. The primary objective of this study was to develop a retrospective image-based movement correction (MC) method and evaluate its implementation on dynamic 2-(1-{6-[(2-(18)F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ((18)F-FDDNP) PET images of cognitively intact controls and patients with Alzheimer's disease (AD).

Alternate JournalJ. Nucl. Med.