A functional genetic link between distinct developmental language disorders.

TitleA functional genetic link between distinct developmental language disorders.
Publication TypeJournal Article
Year of Publication2008
AuthorsVernes, SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcón M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SE
JournalThe New England journal of medicine
Volume359
Issue22
Pagination2337-45
Date Published2008 Nov 27
ISSN1533-4406
KeywordsChild, Chromatin Immunoprecipitation, Down-Regulation, Female, Forkhead Transcription Factors, Gene Expression Regulation, Genetic Markers, Genome-Wide Association Study, Haplotypes, Humans, Language Development Disorders, Male, Membrane Proteins, Nerve Tissue Proteins, Phenotype, Polymerase Chain Reaction, Polymorphism, Single Nucleotide
Abstract

Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment.

Alternate JournalN. Engl. J. Med.