Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis.

TitleSymptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis.
Publication TypeJournal Article
Year of Publication2009
AuthorsVentura, J, Hellemann GS, Thames AD, Koellner V, Nuechterlein KH
JournalSchizophrenia research
Volume113
Issue2-3
Pagination189-99
Date Published2009 Sep
ISSN1573-2509
KeywordsAttention, Cognition Disorders, Databases, Bibliographic, Humans, Learning, Motor Skills, Neuropsychological Tests, Problem Solving, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index
Abstract

Neurocognitive functioning in schizophrenia has received considerable attention because of its robust prediction of functional outcome. Psychiatric symptoms, in particular negative symptoms, have also been shown to predict functional outcome, but have garnered much less attention. The high degree of intercorrelation among all of these variables leaves unclear whether neurocognition has a direct effect on functional outcome or whether that relationship to functional outcome is partially mediated by symptoms.

DOI10.1111/j.1469-8986.2012.01383.x
Alternate JournalSchizophr. Res.