rTMS to the right inferior parietal lobule disrupts self-other discrimination.
|Title||rTMS to the right inferior parietal lobule disrupts self-other discrimination.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Uddin, LQ, Molnar-Szakacs I, Zaidel E, Iacoboni M|
|Journal||Social cognitive and affective neuroscience|
|Date Published||2006 Jun|
|Keywords||Adult, Affect, Discrimination (Psychology), Female, Humans, Male, Parietal Lobe, Recognition (Psychology), Self Concept, Social Perception, Transcranial Magnetic Stimulation|
Self-other discrimination is fundamental to social interaction, however, little is known about the neural systems underlying this ability. In a previous functional magnetic resonance imaging study, we demonstrated that a right fronto-parietal network is activated during viewing of self-faces as compared with the faces of familiar others. Here we used image-guided repetitive transcranial magnetic stimulation (rTMS) to create a 'virtual lesion' over the parietal component of this network to test whether this region is necessary for discriminating self-faces from other familiar faces. The current results indeed show that 1 Hz rTMS to the right inferior parietal lobule (IPL) selectively disrupts performance on a self-other discrimination task. Applying 1 Hz rTMS to the left IPL had no effect. It appears that activity in the right IPL is essential to the task, thus providing for the first time evidence for a causal relation between a human brain area and this high-level cognitive capacity.
|Alternate Journal||Soc Cogn Affect Neurosci|