White-matter abnormalities in brain during early abstinence from methamphetamine abuse.
|Title||White-matter abnormalities in brain during early abstinence from methamphetamine abuse.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Tobias, MC, O'Neill J, Hudkins M, Bartzokis G, Dean AC, London ED|
|Date Published||2010 Mar|
|Keywords||Adult, Amphetamine-Related Disorders, Anisotropy, Brain, Case-Control Studies, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Methamphetamine, Substance Withdrawal Syndrome, Young Adult|
Previous studies revealed microstructural abnormalities in prefrontal white matter and corpus callosum of long-term abstinent chronic methamphetamine abusers. In view of the importance of the early abstinence period in treatment retention, we compared 23 methamphetamine-dependent subjects abstinent from methamphetamine for 7-13 days with 18 healthy comparison subjects. As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence.
|Alternate Journal||Psychopharmacology (Berl.)|