White-matter abnormalities in brain during early abstinence from methamphetamine abuse.

TitleWhite-matter abnormalities in brain during early abstinence from methamphetamine abuse.
Publication TypeJournal Article
Year of Publication2010
AuthorsTobias, MC, O'Neill J, Hudkins M, Bartzokis G, Dean AC, London ED
JournalPsychopharmacology
Volume209
Issue1
Pagination13-24
Date Published2010 Mar
ISSN1432-2072
KeywordsAdult, Amphetamine-Related Disorders, Anisotropy, Brain, Case-Control Studies, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Methamphetamine, Substance Withdrawal Syndrome, Young Adult
Abstract

Previous studies revealed microstructural abnormalities in prefrontal white matter and corpus callosum of long-term abstinent chronic methamphetamine abusers. In view of the importance of the early abstinence period in treatment retention, we compared 23 methamphetamine-dependent subjects abstinent from methamphetamine for 7-13 days with 18 healthy comparison subjects. As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalPsychopharmacology (Berl.)