Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.

TitleQuantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.
Publication TypeJournal Article
Year of Publication2011
AuthorsTillisch, K, Mayer EA, Labus JS
JournalGastroenterology
Volume140
Issue1
Pagination91-100
Date Published2011 Jan
ISSN1528-0012
KeywordsBrain, Brain Mapping, Female, Humans, Irritable Bowel Syndrome, Male, Models, Statistical, Pain, Rectum
Abstract

The responsiveness of the central nervous system is altered in patients with irritable bowel syndrome (IBS). However, because of variations in experimental paradigms, analytic techniques, and reporting practices, little consensus exists on brain responses to visceral stimulation. We aimed to identify brain regions consistently activated by supraliminal rectal stimulation in IBS patients and healthy subjects (controls) by performing a quantitative meta-analysis of published studies.

Alternate JournalGastroenterology