Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.
|Title||Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Tillisch, K, Mayer EA, Labus JS|
|Date Published||2011 Jan|
|Keywords||Brain, Brain Mapping, Female, Humans, Irritable Bowel Syndrome, Male, Models, Statistical, Pain, Rectum|
The responsiveness of the central nervous system is altered in patients with irritable bowel syndrome (IBS). However, because of variations in experimental paradigms, analytic techniques, and reporting practices, little consensus exists on brain responses to visceral stimulation. We aimed to identify brain regions consistently activated by supraliminal rectal stimulation in IBS patients and healthy subjects (controls) by performing a quantitative meta-analysis of published studies.