Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.

TitleLocalized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.
Publication TypeJournal Article
Year of Publication2009
AuthorsThannickal, TC, Nienhuis R, Siegel JM
JournalSleep
Volume32
Issue8
Pagination993-8
Date Published2009 Aug
ISSN0161-8105
KeywordsAged, Aged, 80 and over, Brain Mapping, cataplexy, Cell Count, Female, Glial Fibrillary Acidic Protein, Humans, Hypothalamic Hormones, hypothalamus, Immunoenzyme Techniques, Intracellular Signaling Peptides and Proteins, Male, Melanins, Middle Aged, narcolepsy, Neurons, Neuropeptides, Pituitary Hormones
Abstract

Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not have cataplexy and have normal levels of hypocretin in their cerebrospinal fluid, raising the possibility that their disease is caused by unrelated abnormalities. In this study we examined hypocretin pathology in narcolepsy without cataplexy.

DOI10.1111/j.1365-2869.2012.01023.x
Alternate JournalSleep