Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.
|Title||Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Thannickal, TC, Nienhuis R, Siegel JM|
|Date Published||2009 Aug|
|Keywords||Aged, Aged, 80 and over, Brain Mapping, cataplexy, Cell Count, Female, Glial Fibrillary Acidic Protein, Humans, Hypothalamic Hormones, hypothalamus, Immunoenzyme Techniques, Intracellular Signaling Peptides and Proteins, Male, Melanins, Middle Aged, narcolepsy, Neurons, Neuropeptides, Pituitary Hormones|
Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not have cataplexy and have normal levels of hypocretin in their cerebrospinal fluid, raising the possibility that their disease is caused by unrelated abnormalities. In this study we examined hypocretin pathology in narcolepsy without cataplexy.