Hypocretin (orexin) cell loss in Parkinson’s disease
| Title | Hypocretin (orexin) cell loss in Parkinson’s disease |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Thannickal, TC, Lai Y-Y, Siegel JM |
| Journal | Brain |
| Start Page | 1586 |
| Issue | 130 |
| Date Published | 03/2007 |
| Keywords | Hypocretin, melanin concentrating hormone, narcolepsy, orexin, Parkinson, sleep |
| Abstract | It has recently been reported that Parkinson’s disease (PD) is preceded and accompanied by daytime sleep attacks, nocturnal insomnia, REM sleep behaviour disorder, hallucinations and depression, symptoms which are frequently as troublesome as the motor symptoms of PD. All these symptoms are present in narcolepsy, which is linked to a selective loss of hypocretin (Hcrt) neurons. In this study, the Hcrt system was examined to determine if Hcrt cells are damaged in PD. The hypothalamus of 11 PD (mean age 79 |
