Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy
|Title||Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Thannickal, TC, Nienhuis R, Siegel JM|
|Keywords||cataplexy, Hypocretin, narcolepsy, orexin|
Study Objectives: Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not have cataplexy and have normal levels of hypocretin in their cerebrospinal fluid, raising the possibility that their disease is caused by unrelated abnormalities. In this study we examined hypocretin pathology in narcolepsy without cataplexy. Design: We examined postmortem brain samples, including the hy- pothalamus of 5 narcolepsy with cataplexy patients; one narcolepsy without cataplexy patient whose complete hypothalamus was available (patient 1); one narcolepsy without cataplexy patient with anterior hypo- thalamus available (patient 2); and 6 normal brains. The hypothalamic tissue was immunostained for Hcrt-1, melanin-concentrating hormone (MCH), and glial fibrillary acidic protein (GFAP).
|Short Title||Hypocretin Cell Loss and Narcolepsy Without Cataplexy|