Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

TitleEffects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).
Publication TypeJournal Article
Year of Publication2007
AuthorsSwanson, JM, Moyzis RK, McGough JJ, McCracken JT, Riddle MA, Kollins SH, Greenhill LL, Abikoff HB, Wigal T, Wigal SB, Posner K, Skrobala AM, Davies M, Ghuman JK, Cunningham C, Vitiello B, Stehli A, Smalley SL, Grady D
JournalJournal of child and adolescent psychopharmacology
Volume17
Issue5
Pagination635-46
Date Published2007 Oct
ISSN1044-5463
KeywordsAlleles, Attention Deficit Disorder with Hyperactivity, Child, Preschool, DNA, Dopamine Plasma Membrane Transport Proteins, Female, Gene Frequency, Genotype, Humans, Logistic Models, Male, Minisatellite Repeats, Polymorphism, Genetic, Receptors, Dopamine D4, Reverse Transcriptase Polymerase Chain Reaction, Synaptosomal-Associated Protein 25, Tandem Repeat Sequences
Abstract

In children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and their parents, who were participants of the Preschool ADHD Treatment Study (PATS), we assessed the effect of source of DNA (from buccal or blood cells) on the genotyping success rate and allele percentages for the five polymorphisms in three candidate genes (DAT1, DRD4, and SNAP 25) investigated in the PATS pharmacogenetic study of response to stimulant medication.

DOI10.1016/j.brat.2011.06.001
Alternate JournalJ Child Adolesc Psychopharmacol