Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.
|Title||Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Smalley, SL, Kustanovich V, Minassian SL, Stone JL, Ogdie MN, McGough JJ, McCracken JT, Macphie LI, Francks C, Fisher SE, Cantor RM, Monaco AP, Nelson SF|
|Journal||American journal of human genetics|
|Date Published||2002 Oct|
|Keywords||Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Chromosome Mapping, Chromosomes, Human, Pair 16, Female, Genetic Linkage, Humans, Male|
Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in childhood and likely represents an extreme of normal behavior. ADHD significantly impacts learning in school-age children and leads to impaired functioning throughout the life span. There is strong evidence for a genetic etiology of the disorder, although putative alleles, principally in dopamine-related pathways suggested by candidate-gene studies, have very small effect sizes. We use affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13 (maximum LOD score 4.2; P=.000005), building upon an earlier genomewide scan of this disorder. The region overlaps that highlighted in three genome scans for autism, a disorder in which inattention and hyperactivity are common, and physically maps to a 7-Mb region on 16p13. These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism.
|Alternate Journal||Am. J. Hum. Genet.|