Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.

TitleInfluence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.
Publication TypeJournal Article
Year of Publication2009
AuthorsSmall, GW, Siddarth P, Burggren AC, Kepe V, Ercoli LM, Miller KJ, Lavretsky H, Thompson PM, Cole GM, Huang SC, Phelps ME, Bookheimer SY, Barrio JR
JournalArchives of general psychiatry
Volume66
Issue1
Pagination81-7
Date Published2009 Jan
ISSN1538-3636
KeywordsAged, Alleles, Alzheimer Disease, Apolipoprotein E4, cerebral cortex, Cognition Disorders, Educational Status, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Neurofibrillary Tangles, Neuropsychological Tests, Nitriles, Plaque, Amyloid, Positron-Emission Tomography, Risk Factors, tau Proteins
Abstract

Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer disease that accumulate in the brains of people without dementia years before they develop dementia. Positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), which binds to plaques and tangles in vitro, demonstrate increased cerebral binding in patients with Alzheimer disease compared with cognitively intact controls. Here we investigated whether known risk factors for Alzheimer disease and dementia are associated with FDDNP-PET binding.

Alternate JournalArch. Gen. Psychiatry