Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study.

TitleCognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study.
Publication TypeJournal Article
Year of Publication2008
AuthorsSmall, GW, Siddarth P, Silverman DHS, Ercoli LM, Miller KJ, Lavretsky H, Bookheimer SY, Huang S-C, Barrio JR, Phelps ME
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Volume16
Issue12
Pagination999-1009
Date Published2008 Dec
ISSN1545-7214
KeywordsAdult, Age Factors, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Apolipoprotein E4, cerebral cortex, Cognition Disorders, Cyclooxygenase 2 Inhibitors, Double-Blind Method, Female, Fluorodeoxyglucose F18, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Pyrazoles, Radiopharmaceuticals, Sulfonamides, Treatment Outcome
Abstract

Because anti-inflammatory drugs may delay cognitive decline and influence brain metabolism in normal aging, the authors determined the effects of the cyclooxygenase-2 inhibitor, celecoxib, on cognitive performance and regional cerebral glucose metabolism in nondemented volunteers with mild age-related memory decline.

Alternate JournalAm J Geriatr Psychiatry