PET of brain amyloid and tau in mild cognitive impairment.
|Title||PET of brain amyloid and tau in mild cognitive impairment.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Small, GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang S-C, Satyamurthy N, Phelps ME, Barrio JR|
|Journal||The New England journal of medicine|
|Date Published||2006 Dec 21|
|Keywords||Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Case-Control Studies, Cognition Disorders, Diagnosis, Differential, Female, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurofibrillary Tangles, Nitriles, Plaque, Amyloid, Positron-Emission Tomography, tau Proteins|
Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons with mild cognitive impairment who are at risk for Alzheimer's disease. Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnostics.
|Alternate Journal||N. Engl. J. Med.|