PET of brain amyloid and tau in mild cognitive impairment.

TitlePET of brain amyloid and tau in mild cognitive impairment.
Publication TypeJournal Article
Year of Publication2006
AuthorsSmall, GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang S-C, Satyamurthy N, Phelps ME, Barrio JR
JournalThe New England journal of medicine
Date Published2006 Dec 21
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Case-Control Studies, Cognition Disorders, Diagnosis, Differential, Female, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurofibrillary Tangles, Nitriles, Plaque, Amyloid, Positron-Emission Tomography, tau Proteins

Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons with mild cognitive impairment who are at risk for Alzheimer's disease. Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnostics.

Alternate JournalN. Engl. J. Med.