Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network.

TitleMultimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network.
Publication TypeJournal Article
Year of Publication2011
AuthorsShin, J, Kepe V, Small GW, Phelps ME, Barrio JR
JournalInternational journal of Alzheimer's disease
Volume2011
Pagination687945
Date Published2011
ISSN2090-0252
Abstract

The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporal cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed. [F-18]FDDNP binding in the medial temporal cortex-a key constituent of the DMN-coincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.

Alternate JournalInt J Alzheimers Dis