The genome-wide distribution of background linkage disequilibrium in a population isolate.

TitleThe genome-wide distribution of background linkage disequilibrium in a population isolate.
Publication TypeJournal Article
Year of Publication2001
AuthorsService, SK, Ophoff RA, Freimer NB
JournalHuman molecular genetics
Volume10
Issue5
Pagination545-51
Date Published2001 Mar 1
ISSN0964-6906
KeywordsGenetic Markers, Genetics, Population, Genome, Human, Humans, Linkage Disequilibrium
Abstract

Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage disequilibrium (LD) in the human genome. We examined the genome-wide distribution and magnitude of such background LD (BLD) using 1036 densely spaced microsatellites, in a sample from the demographically well characterized population of the Central Valley of Costa Rica. High levels of BLD were found between linked markers several centiMorgans apart, and although BLD was significantly related to genetic distance between markers it was not spread uniformly throughout the genome. Understanding the forces governing the distribution of BLD in the genome will require similar investigations using a standard set of markers in other populations.

DOI10.1111/j.1528-1167.2012.03574.x
Alternate JournalHum. Mol. Genet.