Association of GSK3B with Alzheimer disease and frontotemporal dementia.

TitleAssociation of GSK3B with Alzheimer disease and frontotemporal dementia.
Publication TypeJournal Article
Year of Publication2008
AuthorsSchaffer, BAJ, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH
JournalArchives of neurology
Date Published2008 Oct
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Brain, Case-Control Studies, Dementia, DNA Mutational Analysis, Exons, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genotype, Glycogen Synthase Kinase 3, Humans, Introns, Male, Middle Aged, Mutation, Phosphorylation, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, tau Proteins

Deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including Alzheimer disease (AD), and about 10% of familial frontotemporal dementia (FTD) cases are caused by mutations in the tau gene. As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found.

Alternate JournalArch. Neurol.