The OCD collaborative genetics study: methods and sample description.

TitleThe OCD collaborative genetics study: methods and sample description.
Publication TypeJournal Article
Year of Publication2006
AuthorsSamuels, JF, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Pinto A, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Bienvenu JO, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang K-Y, Hoehn-Saric R, Nestadt G
JournalAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume141B
Issue3
Pagination201-7
Date Published2006 Apr 5
ISSN1552-4841
KeywordsAdolescent, Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Biomedical Research, Child, Databases, Factual, Family, Family Health, Female, Genotype, Humans, Interviews as Topic, Male, Middle Aged, Obsessive-Compulsive Disorder, Research Design, Sex Factors, Siblings, United States
Abstract

Results from twin and family studies suggest that obsessive-compulsive disorder (OCD) may be transmitted in families but, to date, genes for the disorder have not been identified. The OCD Collaborative Genetics Study (OCGS) is a six-site collaborative genetic linkage study of OCD. Specimens and blinded clinical data will be made available through the National Institute of Mental Health (NIMH) cell repository. In this initial report, we describe the methods of the study and present clinical characteristics of affected individuals for researchers interested in this valuable resource for genetic studies of OCD. The project clinically evaluated and collected blood specimens from 238 families containing 299 OCD-affected sibling pairs and their parents, and additional affected relative pairs, for a genome-wide linkage study. Of the 999 individuals interviewed to date, 624 were diagnosed with "definite" OCD. The mean age of subjects was 36 years (range 7-95). The majority of affected individuals (66%) were female. The mean age at onset of obsessive-compulsive symptoms was 9.5 years. Specific mood disorders, anxiety disorders, eating disorders, and skin picking were more prevalent in female cases, whereas tics, Tourette disorder, and alcohol dependence were more prevalent in male cases. Compared to "definite" cases of OCD, "probable" cases (n = 82) had, on average, later age at onset of obsessive-compulsive symptoms, lower severity score, and fewer numbers of different categories of obsessions and compulsions, and they were less likely to have received treatment for their symptoms.

DOI10.1016/j.brat.2011.06.001
Alternate JournalAm. J. Med. Genet. B Neuropsychiatr. Genet.