Effectiveness of adjunctive antidepressant treatment for bipolar depression.

TitleEffectiveness of adjunctive antidepressant treatment for bipolar depression.
Publication TypeJournal Article
Year of Publication2007
AuthorsSachs, GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, Friedman ES, Bowden CL, Fossey MD, Ostacher MJ, Ketter TA, Patel J, Hauser P, Rapport D, Martinez JM, Allen MH, Miklowitz DJ, Otto MW, Dennehy EB, Thase ME
JournalThe New England journal of medicine
Date Published2007 Apr 26
KeywordsAdult, Antidepressive Agents, Second-Generation, Antimanic Agents, Bipolar disorder, Bupropion, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Paroxetine, Treatment Outcome

Episodes of depression are the most frequent cause of disability among patients with bipolar disorder. The effectiveness and safety of standard antidepressant agents for depressive episodes associated with bipolar disorder (bipolar depression) have not been well studied. Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania.

Alternate JournalN. Engl. J. Med.