Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations.

TitleProteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations.
Publication TypeJournal Article
Year of Publication2012
AuthorsRingman, JM, Schulman H, Becker C, Jones T, Bai Y, Immermann F, Cole G, Sokolow S, Gylys K, Geschwind DH, Cummings JL, Wan HI
JournalArchives of neurology
Volume69
Issue1
Pagination96-104
Date Published2012 Jan
ISSN1538-3687
KeywordsAdult, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Cerebrospinal Fluid Proteins, Chromatography, Liquid, DNA Mutational Analysis, Female, Humans, Male, Middle Aged, Models, Biological, Mutation, Peptide Fragments, Presenilin-1, Proteomics, Statistics, Nonparametric, Tandem Mass Spectrometry, tau Proteins
Abstract

To identify cerebrospinal fluid (CSF) protein changes in persons who will develop familial Alzheimer disease (FAD) due to PSEN1 and APP mutations, using unbiased proteomics.

DOI10.1038/nn.3115
Alternate JournalArch. Neurol.