Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease.

TitleCerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsRingman, JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys K, Cummings JL, Cole GM
JournalDementia and geriatric cognitive disorders
Volume33
Issue1
Pagination1-5
Date Published2012
ISSN1421-9824
KeywordsAge Factors, Aged, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Apolipoproteins E, Biological Markers, Cohort Studies, DNA, Early Diagnosis, Female, Genotype, Heterozygote, Humans, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Presenilin-1, tau Proteins
Abstract

Biological markers of utility in tracking Alzheimer's disease (AD) during the presymptomatic prodromal phase are important for prevention studies. Changes in cerebrospinal fluid (CSF) levels of 42-amino-acid β-amyloid (Aβ(42)), total tau protein (t-tau) and phosphorylated tau at residue 181 (p-tau(181)) during this state are incompletely characterized.

DOI10.1111/j.1460-9568.2012.08054.x
Alternate JournalDement Geriatr Cogn Disord