The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.

TitleThe brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.
Publication TypeJournal Article
Year of Publication2007
AuthorsRibeiro, L, Busnello JV, Cantor RM, Whelan F, Whittaker P, Deloukas P, Wong M-L, Licinio J
Date Published2007 Aug 6
KeywordsAdult, Amino Acid Substitution, Brain, Brain Chemistry, Brain-Derived Neurotrophic Factor, Depressive Disorder, DNA Mutational Analysis, Female, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genotype, Homozygote, Humans, Male, Methionine, Mexican Americans, Middle Aged, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Valine

The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.

Alternate JournalNeuroreport