Forebrain steroid levels fluctuate rapidly during social interactions.

TitleForebrain steroid levels fluctuate rapidly during social interactions.
Publication TypeJournal Article
Year of Publication2008
AuthorsRemage-Healey, L, Maidment NT, Schlinger BA
JournalNature neuroscience
Volume11
Issue11
Pagination1327-34
Date Published2008 Nov
ISSN1546-1726
KeywordsAnalysis of Variance, Animals, Auditory Cortex, Behavior, Animal, Early Growth Response Protein 1, Estradiol, Estrogen Antagonists, Fadrozole, Female, Finches, Gene Expression Regulation, Interpersonal Relations, Male, microdialysis, Neurotransmitter Agents, Testosterone
Abstract

Neurosteroids are powerful modulators of brain function and behavior, yet their dynamics in the brain have remained elusive. Using in vivo microdialysis in male zebra finches, we found that local estradiol levels increased rapidly in the forebrain during social interactions with females. Furthermore, when males were exposed to other males' songs, local estradiol levels also increased and testosterone levels dropped in a cortical/pallial auditory region that is analogous to mammalian auditory cortex. We also found that local estradiol and testosterone levels were differentially regulated in this same region by the conventional neurotransmitters glutamate and GABA, respectively. This study provides direct evidence that forebrain steroid levels are acutely and differentially regulated during social behavior in a region-specific manner and in a rapid time course similar to that of traditional neuromodulators.

DOI10.3791/1355
Alternate JournalNat. Neurosci.