Concussive brain injury enhances fear learning and excitatory processes in the amygdala.
|Title||Concussive brain injury enhances fear learning and excitatory processes in the amygdala.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Reger, ML, Poulos AM, Buen F, Giza CC, Hovda DA, Fanselow MS|
|Date Published||2012 Feb 15|
|Keywords||Affective Symptoms, Amygdala, Animals, Behavior, Animal, Brain Concussion, Conditioning (Psychology), Fear, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Hippocampus, Humans, Isoenzymes, memory, Models, Animal, Rats, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate, Risk Factors, Stress Disorders, Post-Traumatic, Synaptic Transmission|
Mild traumatic brain injury (cerebral concussion) results in cognitive and emotional dysfunction. These injuries are a significant risk factor for the development of anxiety disorders, including posttraumatic stress disorder. However, because physically traumatic events typically occur in a highly emotional context, it is unknown whether traumatic brain injury itself is a cause of augmented fear and anxiety.
|Alternate Journal||Biol. Psychiatry|