Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation.

TitleCellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation.
Publication TypeJournal Article
Year of Publication2004
AuthorsRedwine, L, Dang J, Irwin M
JournalBrain, behavior, and immunity
Volume18
Issue4
Pagination333-40
Date Published2004 Jul
ISSN0889-1591
KeywordsAdult, Biological Markers, Cell Adhesion Molecules, Circadian Rhythm, Humans, Integrins, L-Selectin, Lymphocyte Count, Lymphocytes, Macrophage-1 Antigen, Male, Middle Aged, Monocytes, Reference Values, sleep, sleep deprivation, Sleep Stages
Abstract

Sleep is hypothesized to have a role in the regulation of the immune system. This study evaluated the nocturnal expression of cellular adhesion molecules, Mac-1 and L-selectin on monocytes and lymphocytes during a full nights sleep and following a partial night of sleep deprivation (PSD). Healthy male subjects (n=16) had an increase in the percentage of Mac-1 positive lymphocytes across the baseline night. Whereas, the percentage of Mac-1 positive lymphocytes was reduced and L-selectin positive lymphocytes and monocytes were greater during the PSD night as compared to the baseline night. These data indicate that acute sleep disruption is associated with alterations in cellular adhesion molecule expression, with implications for the regulation of immune cell trafficking.

DOI10.1111/j.1399-5618.2011.00969.x
Alternate JournalBrain Behav. Immun.