A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.

TitleA human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.
Publication TypeJournal Article
Year of Publication2011
AuthorsRay, LA, Chin PF, Heydari A, Miotto K
JournalPsychopharmacology
Volume217
Issue3
Pagination341-51
Date Published2011 Oct
ISSN1432-2072
KeywordsAdult, Aged, Alcoholic Intoxication, Alcoholism, Antipsychotic Agents, Cues, Dibenzothiazepines, Double-Blind Method, Ethanol, Female, Humans, Male, Middle Aged, Pilot Projects, Questionnaires, Substance Withdrawal Syndrome, Treatment Outcome, Young Adult
Abstract

The available treatments for alcoholism are only modestly effective, and patients vary widely in their treatment response. Quetiapine, an atypical antipsychotic medication with antagonist activity at D1 and D2, 5-HT(1A) and 5-HT(2A), H(1), and α1 and α2 receptors was shown to promote abstinence, reduce drinking days, and reduce heavy drinking days in a 12-week double-blind placebo-controlled trial.

DOI10.1038/npp.2011.192
Alternate JournalPsychopharmacology (Berl.)