A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.
|Title||A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Ray, LA, Chin PF, Heydari A, Miotto K|
|Date Published||2011 Oct|
|Keywords||Adult, Aged, Alcoholic Intoxication, Alcoholism, Antipsychotic Agents, Cues, Dibenzothiazepines, Double-Blind Method, Ethanol, Female, Humans, Male, Middle Aged, Pilot Projects, Questionnaires, Substance Withdrawal Syndrome, Treatment Outcome, Young Adult|
The available treatments for alcoholism are only modestly effective, and patients vary widely in their treatment response. Quetiapine, an atypical antipsychotic medication with antagonist activity at D1 and D2, 5-HT(1A) and 5-HT(2A), H(1), and α1 and α2 receptors was shown to promote abstinence, reduce drinking days, and reduce heavy drinking days in a 12-week double-blind placebo-controlled trial.
|Alternate Journal||Psychopharmacology (Berl.)|