Cerebral metabolic patterns in untreated postmenopausal women with major depressive disorder.

TitleCerebral metabolic patterns in untreated postmenopausal women with major depressive disorder.
Publication TypeJournal Article
Year of Publication2008
AuthorsRasgon, NL, Kenna HA, Geist C, Small G, Silverman D
JournalPsychiatry research
Volume164
Issue1
Pagination77-80
Date Published2008 Oct 30
ISSN0165-1781
Keywordscerebral cortex, Depressive Disorder, Major, Diagnostic and Statistical Manual of Mental Disorders, Estrogens, Female, Frontal Lobe, Humans, Middle Aged, Pilot Projects, pons, Postmenopause
Abstract

Cerebral metabolic rates were assessed using [(18)F]-fluorodeoxyglucose positron emission tomography in six naturally postmenopausal women with untreated unipolar depression and 11 matched controls. All subjects were hormone therapy-naive and medication-free. Findings include hypermetabolism in the middle frontal gyrus and Broca regions, and hypometabolism in the pons among depressed compared with non-depressed women.

Alternate JournalPsychiatry Res